Molecular Marker Discovery and Evaluation: EGF rs1897990 and rs1524106 Variants in a China Lung Adenocarcinoma Young Population

IF 2.3 4区医学 Q3 RESPIRATORY SYSTEM

Clinical Respiratory Journal Pub Date : 2025-07-22 DOI:10.1111/crj.70113

Huiwen Pan, Xiangyang Wang, Lijie Zheng, Jinye Wang, Guowen Ding, Jingfeng Zhu, Zhijie Fang

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引用次数: 0

Abstract

Objective

The objective of this study is to investigate the genetic susceptibility and risk factors of EGF gene rs1897990 and rs1524106 in lung adenocarcinoma young patients aged ≤ 45 years.

Methods

A case–control study was conducted. DNA was extracted and identified from 88 samples from case and control groups by single-nucleotide polymorphism assay. PCR amplification was performed by TaqMan probe method, and the factors of smoking, drinking, sex, and age were also included. To investigate the clinical factors and genotyping differences between case and control groups.

Results

Smoking was an influential factor in young lung adenocarcinoma patients. The mutation frequency of EGF gene rs1897990 CT heterozygous mutant was different between the two groups (p = 0.021). The T alleles of EGF rs1897990 and rs1524106 were significantly different between the two groups (p = 0.034 and p = 0.023).

Conclusions

The young lung adenocarcinoma population (≤ 45 years old) is susceptible to EGF rs1897990 and rs1524106 variants, with smoking being another risk factor. Additionally, smoking may enhance the risk of EGF rs1897990 and rs1524106 variants threatening the development of lung adenocarcinoma.

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分子标记的发现和评价：中国肺腺癌年轻人群中EGF rs1897990和rs1524106变异

目的探讨年龄≤45岁青年肺腺癌患者EGF基因rs1897990和rs1524106的遗传易感性及危险因素。方法采用病例-对照研究。分别从病例组和对照组的88份样品中提取DNA并进行单核苷酸多态性分析。采用TaqMan探针法进行PCR扩增，并考虑吸烟、饮酒、性别、年龄等因素。探讨病例组与对照组的临床因素及基因分型差异。结果吸烟是影响青年肺腺癌发病的重要因素。两组间EGF基因rs1897990 CT杂合突变体突变频率差异有统计学意义（p = 0.021）。EGF的T等位基因rs1897990和rs1524106在两组间差异有统计学意义（p = 0.034和p = 0.023）。结论年轻肺腺癌人群（≤45岁）易发生EGF rs1897990和rs1524106变异，吸烟是另一个危险因素。此外，吸烟可能增加威胁肺腺癌发展的EGF rs1897990和rs1524106变异的风险。

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来源期刊

Clinical Respiratory Journal 医学-呼吸系统

CiteScore

3.70

自引率

0.00%

发文量

104

审稿时长

>12 weeks

期刊介绍： Overview Effective with the 2016 volume, this journal will be published in an online-only format. Aims and Scope The Clinical Respiratory Journal (CRJ) provides a forum for clinical research in all areas of respiratory medicine from clinical lung disease to basic research relevant to the clinic. We publish original research, review articles, case studies, editorials and book reviews in all areas of clinical lung disease including: Asthma Allergy COPD Non-invasive ventilation Sleep related breathing disorders Interstitial lung diseases Lung cancer Clinical genetics Rhinitis Airway and lung infection Epidemiology Pediatrics CRJ provides a fast-track service for selected Phase II and Phase III trial studies. Keywords Clinical Respiratory Journal, respiratory, pulmonary, medicine, clinical, lung disease, Abstracting and Indexing Information Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Embase (Elsevier) Health & Medical Collection (ProQuest) Health Research Premium Collection (ProQuest) HEED: Health Economic Evaluations Database (Wiley-Blackwell) Hospital Premium Collection (ProQuest) Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) ProQuest Central (ProQuest) Science Citation Index Expanded (Clarivate Analytics) SCOPUS (Elsevier)