Combined Associations of Type 2 Diabetes and Peripheral Neuropathy With Device-Measured Physical Activity and Sedentary Behaviour—The Maastricht Study

IF 6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Touria Ahaouari, Brenda Berendsen, Nicolaas Schaper, Hans Bosma, Marleen van Greevenbroek, Bastiaan de Galan, Miranda T. Schram, Hans Savelberg, Annemarie Koster
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Abstract

Objective

Peripheral neuropathy (PN) is a common complication of type 2 diabetes mellitus (T2DM). In this study, we determined the independent and combined associations of T2DM and PN with device-based measures of physical activity levels and sedentary behaviour.

Materials and Methods

Cross-sectional data from The Maastricht Study were used (N: 6471, age 59.8 ± 8.8). T2DM was determined with an oral glucose tolerance test and PN was, using a neurothesiometer, defined as an impaired vibration perception threshold (iVPT), that is exceeding 25 V in either one or both halluces. Physical activity and sedentary behaviour outcomes were derived through 8 days of activPAL accelerometer measurement, worn 24 h/day. Multiple linear regression analyses were used with adjustment for demographic, lifestyle and health-related indicators.

Results

In the fully adjusted model, the combined presence of T2DM and iVPT presented the lowest step count (−1407 steps/day [95% CI: −1851, −963]), and showed the lowest time in light-intensity (−27.2 min/day [−38.6, −15.8]) and moderate-to-vigorous physical activity (−9.5 min/day [−12.6, −6.5]). Moreover, those with both conditions had the highest sedentary time (+33.3 min/day [21.4, 45.2]) and longest sedentary bout durations (+1.0 min/bout [0.6, 1.4) compared with those without these conditions.

Discussion

T2DM and PN were both independently associated with lower levels of physical activity and higher levels of sedentary time. The combination of T2DM with PN was associated with particularly low levels of physical activity and higher levels of sedentary time, indicating an additive association. Strategies to improve physical activity in these individuals should address both conditions.

Abstract Image

2型糖尿病和周围神经病变与器械测量的身体活动和久坐行为的联合关联——马斯特里赫特研究
目的周围神经病变(PN)是2型糖尿病(T2DM)的常见并发症。在这项研究中,我们确定了T2DM和PN与基于设备的身体活动水平和久坐行为的独立和联合关联。材料与方法采用来自马斯特里赫特研究的横断面数据(N: 6471,年龄59.8±8.8)。T2DM采用口服葡萄糖耐量试验,PN采用神经测量仪,定义为振动感知阈值受损(iVPT),其中一个或两个幻觉均超过25 V。身体活动和久坐行为的结果是通过8天的activPAL加速度计测量得出的,每天佩戴24小时。采用多元线性回归分析,调整人口统计学、生活方式和健康相关指标。结果在完全调整后的模型中,T2DM和iVPT合并出现的患者步数最低(- 1407步/天[95% CI: - 1851, - 963]),低强度运动(- 27.2分钟/天[- 38.6,- 15.8])和中高强度运动(- 9.5分钟/天[- 12.6,- 6.5])的时间最低。此外,与没有这些疾病的人相比,患有这两种疾病的人久坐时间最长(+33.3分钟/天[21.4,45.2]),久坐时间最长(+1.0分钟/次[0.6,1.4])。T2DM和PN都与低水平的身体活动和高水平的久坐时间独立相关。T2DM合并PN尤其与低水平的身体活动和高水平的久坐时间相关,表明两者存在叠加性关联。改善这些人身体活动的策略应该同时解决这两种情况。
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来源期刊
Diabetes/Metabolism Research and Reviews
Diabetes/Metabolism Research and Reviews 医学-内分泌学与代谢
CiteScore
17.20
自引率
2.50%
发文量
84
审稿时长
4-8 weeks
期刊介绍: Diabetes/Metabolism Research and Reviews is a premier endocrinology and metabolism journal esteemed by clinicians and researchers alike. Encompassing a wide spectrum of topics including diabetes, endocrinology, metabolism, and obesity, the journal eagerly accepts submissions ranging from clinical studies to basic and translational research, as well as reviews exploring historical progress, controversial issues, and prominent opinions in the field. Join us in advancing knowledge and understanding in the realm of diabetes and metabolism.
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