Suicide attempts in elderly Han Chinese patients with major depressive disorder: prevalence and associated factors

IF 2.1 4区心理学 Q2 PSYCHOLOGY, EXPERIMENTAL

Acta Psychologica Pub Date : 2025-07-22 DOI:10.1016/j.actpsy.2025.105228

Xiaofan Zhou , Yu Zhou , Xiang Yang Zhang

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引用次数: 0

Abstract

Objective

Suicide attempts (SA) are common in elderly patients with major depressive disorder (MDD), but few studies have focused on the prevalence and associated factors in elderly Chinese Han patients with MDD.

Method

A total of 266 first episode and drug naïve older patients with MDD (age ≥ 50 years) were recruited. We measured depressive symptoms, anxiety symptoms and psychotic symptoms by the Hamilton Depression Rating Scale (HAMD), the Hamilton Anxiety Rating Scale (HAMA), the positive subscale of the Positive and Negative Syndrome Scale (PANSS) and the Clinical General Impression Inventory (CGIS). Fasting serum samples were collected to measure thyroid hormone levels and metabolic parameters.

Results

The prevalence of SA was 24.4 %. Patients with SA had higher HAMD, HAMA, PANSS positive subscale and CGI-S scores, as well as higher levels of TSH, TgAb, TPOAb, FBG, TC, LDL-C, TG, and systolic and diastolic blood pressure. Logistic regression analysis showed that suicide attempts were correlated with HAMA score, CGI-S score and TC levels in elderly patients with MDD.

Conclusions

The findings show a high prevalence of suicide attempts in elderly patients with MDD. In elderly patients with MDD, severity of anxiety, CGI-S score and TC levels were associated factors for suicide attempts.

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汉族老年抑郁症患者的自杀倾向：患病率及相关因素

目的老年重度抑郁障碍（MDD）患者自杀未遂（SA）较为常见，但对中国汉族老年重度抑郁障碍患者的患病率及其相关因素的研究较少。方法共招募266例首发并服药naïve的老年MDD患者（年龄≥50岁）。采用汉密尔顿抑郁评定量表（HAMD）、汉密尔顿焦虑评定量表（HAMA）、正阴性综合征量表（PANSS）阳性子量表和临床总体印象量表（CGIS）对抑郁症状、焦虑症状和精神病症状进行测量。采集空腹血清样本，测定甲状腺激素水平和代谢参数。结果SA患病率为24.4%。SA患者有较高的HAMD、HAMA、PANSS阳性亚量表和CGI-S评分，以及较高的TSH、TgAb、TPOAb、FBG、TC、LDL-C、TG、收缩压和舒张压。Logistic回归分析显示，老年MDD患者自杀企图与HAMA评分、CGI-S评分、TC水平相关。结论老年重度抑郁症患者有较高的自杀倾向。在老年MDD患者中，焦虑严重程度、CGI-S评分和TC水平是自杀企图的相关因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Psychologica PSYCHOLOGY, EXPERIMENTAL-

CiteScore

3.00

自引率

5.60%

发文量

274

审稿时长

36 weeks

期刊介绍： Acta Psychologica publishes original articles and extended reviews on selected books in any area of experimental psychology. The focus of the Journal is on empirical studies and evaluative review articles that increase the theoretical understanding of human capabilities.