Emerging advances in spinal cord injury: An introductory overview.

Abstract

Spinal cord injury (SCI) remains a devastating condition with limited treatment options. This Focus Issue highlights recent clinical and translational advances across the continuum of SCI care from prehospital coordination to novel therapeutics. The articles cover multidisciplinary strategies during the early post-injury phase, including acute pre-hospital care and pragmatic alternatives for settings with limited medical resources. A historical perspective on the evolution of surgical timing and a comprehensive reappraisal of the pathophysiology of central cord syndrome provide valuable clinical context. Emerging diagnostic innovations are prominently featured, including novel biomarkers such as cerebrospinal fluid pressure dynamics, quantitative MRI, and navigated transcranial magnetic stimulation, which offer the potential to refine diagnosis and personalize prognostication. In parallel, emerging therapeutic technologies such as 3D-printed surgical guides and clinical applications of stem cell therapies represent significant advances in addressing long-standing challenges. The issue also includes comprehensive reviews of current classification systems and diagnostic criteria for both spine fractures and degenerative cervical myelopathy. Together, these contributions provide a multidisciplinary overview of the evolving landscape in SCI research and care, bridging basic science with clinical practice across diverse healthcare settings.