Therapeutic effect of intense pulsed light in ocular demodicosis: A systematic review and meta-analysis.

IF 3.7 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye Pub Date : 2025-07-20 DOI:10.1016/j.clae.2025.102477

Hsin-Ming Liu, Shannon Su, Cher-Ming Liou, Ann Yi-Chiun Chuang

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引用次数: 0

Abstract

Aims: To assess the effect of intense pulsed light (IPL) on reducing ocular demodicosis.

Methods: A systematic literature search was conducted up to March 8, 2025, using the PubMed, Embase, Google Scholar, and Cochrane Central Register of Controlled Trials databases. Randomized controlled trials (RCTs) or non-RCTs with Demodex measurements before and after IPL therapy were included.

Results: Six trials (five RCTs + one non-RCT) involving 329 adults were included. The overall risk of bias was assessed as low to moderate, and the certainty of evidence for all outcomes was considered low. IPL reduced Demodex mites per 100 eyelashes, with a mean difference (MD) of -7.80 (-16.36 to 0.76) with moderate heterogeneity (p = 0.11, I² = 47 %) when considering only RCTs. The risk ratio of Demodex eradication was 1.41 (1.18 to 1.69, I² = 0 %, p = 0.72) and was significant in both the IPL with meibomian gland expression (MGX) subgroup (1.49, 1.17-1.91) and IPL alone subgroup (1.32, 1.02-1.72). No major adverse events were reported.

Conclusion: IPL, either alone or in combination with MGX, demonstrates a trend toward reducing Demodex infestation with no major adverse events reported. However, its effect on mite count reduction has not reached statistical significance. Further studies are needed to establish an optimal IPL treatment protocol.

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强脉冲光治疗眼蠕虫病的疗效：系统回顾和荟萃分析。

目的：探讨强脉冲光（IPL）治疗眼部蠕虫病的效果。方法：使用PubMed、Embase、谷歌Scholar和Cochrane Central Register of Controlled Trials数据库进行系统文献检索，检索时间截止到2025年3月8日。纳入IPL治疗前后Demodex测量的随机对照试验（rct）或非rct。结果：纳入6项试验（5项rct + 1项非rct），涉及329名成年人。总体偏倚风险被评估为低至中等，所有结果的证据确定性被认为较低。仅考虑随机对照试验时，IPL每100根睫毛减少蠕形螨，平均差异（MD）为-7.80(-16.36至0.76)，具有中等异质性（p = 0.11, I2 = 47%）。蠕形螨被根除的危险比为1.41 (1.18 ~ 1.69,I2 = 0%, p = 0.72)，在有眉板腺表达的IPL （MGX）亚组（1.49,1.17 ~ 1.91）和单独IPL亚组（1.32,1.02 ~ 1.72）中均有显著性差异。无重大不良事件报告。结论：IPL，无论是单独使用还是与MGX联合使用，都显示出减少蠕形螨感染的趋势，没有重大不良事件的报道。但其对螨数的减少效果尚未达到统计学意义。需要进一步的研究来建立一个最佳的IPL治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Lens & Anterior Eye OPHTHALMOLOGY-

CiteScore

7.60

自引率

18.80%

发文量

198

审稿时长

55 days

期刊介绍： Contact Lens & Anterior Eye is a research-based journal covering all aspects of contact lens theory and practice, including original articles on invention and innovations, as well as the regular features of: Case Reports; Literary Reviews; Editorials; Instrumentation and Techniques and Dates of Professional Meetings.