Risk of transfusion-transmitted infections among returned high-risk deferred donors: A cohort study.

IF 1.8 4区医学 Q3 HEMATOLOGY

Vox Sanguinis Pub Date : 2025-07-20 DOI:10.1111/vox.70080

Amir Teimourpour, Sedigheh Amini-Kafiabad, Amir Masoud Nazemi, Sheila F O'Brien, Mahtab Maghsudlu

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Abstract

Background and objectives: Blood donor selection is crucial for ensuring safe blood supply. A well-designed donor selection system helps in maintaining donor engagement by minimizing unnecessary exclusion while safeguarding transfusion safety. We aimed to assess the risk of transfusion-transmitted infections (TTIs) among high-risk deferred donors to evaluate deferral criteria efficacy.

Materials and methods: This study included data from volunteers who were temporarily deferred because of bloodletting, high-risk sexual contact, tattooing, endoscopy and needle sticks, as well as from eligible donors who donated blood over a 12-month period. These donors were followed up for 4 years. The results of infectious confirmatory tests, including hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV), of returned donors who donated blood were extracted from the database. Risk ratio (RR) of TTI was calculated to compare the risk between eligible and deferred donors.

Results: The data from 601,177 returned, deferred and eligible blood donors were analysed. The risk of TTIs was significantly higher in the deferred group compared to eligible donor group (RR: 3.58; 95% confidence interval [CI]: 2.68-4.80; p <0.001). The risk of TTIs was significantly higher in those deferred for bloodletting (RR = 4.85; 95% CI: 3.41-6.91; p < 0.001), tattooing (RR = 3.53; 95% CI: 1.26-3.83; p = 0.029) and high-risk sexual contact (RR = 2.19; 95% CI: 1.26-3.83; p = 0.011).

Conclusion: Individuals with a history of bloodletting, tattooing or high-risk sexual contact were at a higher risk of HBV and HCV infection, highlighting the effectiveness of donor selection procedures. Endoscopy and needle stick injuries were not associated with an increased TTI risk, emphasizing the need for further research to reassess these deferral criteria. Blood centres should monitor the efficacy of donor selection criteria while emphasizing proper donor selection and counselling.

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返回高风险延迟献血者的输血传播感染风险：一项队列研究。

背景和目的：献血者的选择是确保安全血液供应的关键。精心设计的献血者选择系统有助于通过最大限度地减少不必要的排斥来维持献血者参与，同时保障输血安全。我们旨在评估高风险延迟献血者中输血传播感染（tti）的风险，以评估延迟标准的有效性。材料和方法：本研究的数据来自因放血、高风险性接触、纹身、内窥镜检查和针扎而暂时推迟的志愿者，以及在12个月内献血的合格献血者。这些捐赠者被随访了4年。从数据库中提取了回国献血者的感染性确认试验结果，包括乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和人类免疫缺陷病毒（HIV）。计算TTI的风险比（RR），比较符合条件和延期供者的风险。结果：分析了601177名返回、延迟和符合条件的献血者的数据。延迟供体组发生tti的风险明显高于合格供体组(RR: 3.58；95%置信区间[CI]: 2.68-4.80；p结论：有放血史、纹身史或高危性接触史的个体感染HBV和HCV的风险更高，这突出了供体选择程序的有效性。内窥镜检查和针刺损伤与TTI风险增加无关，强调需要进一步研究以重新评估这些延迟标准。血液中心应监测献血者选择标准的有效性，同时强调适当的献血者选择和咨询。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vox Sanguinis 医学-血液学

CiteScore

4.40

自引率

11.10%

发文量

156

审稿时长

6-12 weeks

期刊介绍： Vox Sanguinis reports on important, novel developments in transfusion medicine. Original papers, reviews and international fora are published on all aspects of blood transfusion and tissue transplantation, comprising five main sections: 1) Transfusion - Transmitted Disease and its Prevention: Identification and epidemiology of infectious agents transmissible by blood; Bacterial contamination of blood components; Donor recruitment and selection methods; Pathogen inactivation. 2) Blood Component Collection and Production: Blood collection methods and devices (including apheresis); Plasma fractionation techniques and plasma derivatives; Preparation of labile blood components; Inventory management; Hematopoietic progenitor cell collection and storage; Collection and storage of tissues; Quality management and good manufacturing practice; Automation and information technology. 3) Transfusion Medicine and New Therapies: Transfusion thresholds and audits; Haemovigilance; Clinical trials regarding appropriate haemotherapy; Non-infectious adverse affects of transfusion; Therapeutic apheresis; Support of transplant patients; Gene therapy and immunotherapy. 4) Immunohaematology and Immunogenetics: Autoimmunity in haematology; Alloimmunity of blood; Pre-transfusion testing; Immunodiagnostics; Immunobiology; Complement in immunohaematology; Blood typing reagents; Genetic markers of blood cells and serum proteins: polymorphisms and function; Genetic markers and disease; Parentage testing and forensic immunohaematology. 5) Cellular Therapy: Cell-based therapies; Stem cell sources; Stem cell processing and storage; Stem cell products; Stem cell plasticity; Regenerative medicine with cells; Cellular immunotherapy; Molecular therapy; Gene therapy.