Panpan Jiao, Xinmiao Ni, Jingsong Wang, Xiangxiang Yang, Haonan Mei, Xiaodong Weng, Lei Wang, Zhiyuan Chen, Qingyuan Zheng, Xiuheng Liu
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引用次数: 0
Abstract
Background: In the exploration of the pathogenesis of overactive bladder (OAB), emerging evidence suggests a potential link between OAB and obesity. However, the association between visceral fat accumulation and OAB has not been definitively established. The aim of the study is to analyze and establish the relationship between visceral adiposity index (VAI) and OAB in large population studies.
Methods: The study included 13,694 participants from the National Health and Nutrition Examination Survey (NHANES) database covering the years 2007 to 2018. VAI was calculated using waist circumference (WC), body mass index (BMI), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-c). OAB was defined via the Overactive Bladder Symptom Score (OABSS ≥3). It utilized weighted multivariable logistic regression to analyze the association between VAI and OAB, as well as the relationship between the two across various subgroups. Additionally, restricted cubic spline (RCS) analysis was employed to explore the nonlinear relationship between VAI and OAB.
Results: Weighted multivariable logistic regression indicated a significant association between VAI and OAB (P<0.05). After adjusting for covariates, a notable association was found between the "Q4" of VAI and the occurrence of OAB (all P<0.05). Subgroup analysis results were consistent with those of the overall population (P for interaction >0.05). RCS revealed a nonlinear positive dose-response relationship (P<0.001), with a significant inflection point at VAI =1.41.
Conclusions: The study identified a nonlinear positive dose-response relationship between VAI and the occurrence of OAB. Incorporating VAI into comprehensive management strategies for OAB is a meaningful exploration.
期刊介绍:
ranslational Andrology and Urology (Print ISSN 2223-4683; Online ISSN 2223-4691; Transl Androl Urol; TAU) is an open access, peer-reviewed, bi-monthly journal (quarterly published from Mar.2012 - Dec. 2014). The main focus of the journal is to describe new findings in the field of translational research of Andrology and Urology, provides current and practical information on basic research and clinical investigations of Andrology and Urology. Specific areas of interest include, but not limited to, molecular study, pathology, biology and technical advances related to andrology and urology. Topics cover range from evaluation, prevention, diagnosis, therapy, prognosis, rehabilitation and future challenges to urology and andrology. Contributions pertinent to urology and andrology are also included from related fields such as public health, basic sciences, education, sociology, and nursing.