{"title":"Clinical Features Associated With Fatigue in People With Fibrotic Interstitial Lung Disease: Cross-Sectional Study.","authors":"Shohei Kawachi, Mariana Hoffman, Anne E Holland","doi":"10.1111/resp.70091","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objective: </strong>Fatigue significantly impacts quality of life in fibrosing interstitial lung diseases (fILDs). Oxyhaemoglobin desaturation contributes to fatigue in chronic obstructive pulmonary disease; however, this has not been investigated in fILD. This study aimed to elucidate the relationship between fatigue and clinical features, including oxyhaemoglobin desaturation, in fILD.</p><p><strong>Methods: </strong>Participants had stable fILD with exertional desaturation (SpO<sub>2</sub> ≤ 88% on 6-min walk test, 6MWT). Univariate and multivariate analyses were performed with fatigue as the dependent variable and the clinical features related to fatigue as independent variables. Fatigue was assessed using the Fatigue Severity Scale (FSS). Independent variables were specified a priori using directed acyclic graphs based on previous studies: age, BMI, severity (FVC%), Dyspnoea-12 score, physical activity (mean daily steps), desaturation (nadir SpO<sub>2</sub> during 6MWT and during daily life), presence of corticosteroids, and obstructive sleep apnoea.</p><p><strong>Results: </strong>One hundred and sixteen participants were included with mean (SD) age of 70.9 (9.8), FVC% of 69.8 (16.1). Seventy-two participants (62%) had substantial fatigue (≥ 36 on FSS). Univariate analysis showed no relationship between FSS and nadir SpO<sub>2</sub> during 6MWT (r = -0.03, p = 0.76) or minimum SpO<sub>2</sub> during daily life (r = 0.04, p = 0.74). Multiple regression analyses showed associations between higher fatigue on FSS and greater breathlessness on Dyspnoea-12 (standardised beta = 0.546, p < 0.001) and lower daily steps (standardised beta = -0.188, p = 0.02).</p><p><strong>Conclusion: </strong>Dyspnoea and physical activity are associated with fatigue in fILD. Exertional desaturation does not appear to contribute to fatigue in this group.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Registry (URL: https://clinicaltrials.gov/study/NCT03737409).</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.3000,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respirology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/resp.70091","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0
Abstract
Background and objective: Fatigue significantly impacts quality of life in fibrosing interstitial lung diseases (fILDs). Oxyhaemoglobin desaturation contributes to fatigue in chronic obstructive pulmonary disease; however, this has not been investigated in fILD. This study aimed to elucidate the relationship between fatigue and clinical features, including oxyhaemoglobin desaturation, in fILD.
Methods: Participants had stable fILD with exertional desaturation (SpO2 ≤ 88% on 6-min walk test, 6MWT). Univariate and multivariate analyses were performed with fatigue as the dependent variable and the clinical features related to fatigue as independent variables. Fatigue was assessed using the Fatigue Severity Scale (FSS). Independent variables were specified a priori using directed acyclic graphs based on previous studies: age, BMI, severity (FVC%), Dyspnoea-12 score, physical activity (mean daily steps), desaturation (nadir SpO2 during 6MWT and during daily life), presence of corticosteroids, and obstructive sleep apnoea.
Results: One hundred and sixteen participants were included with mean (SD) age of 70.9 (9.8), FVC% of 69.8 (16.1). Seventy-two participants (62%) had substantial fatigue (≥ 36 on FSS). Univariate analysis showed no relationship between FSS and nadir SpO2 during 6MWT (r = -0.03, p = 0.76) or minimum SpO2 during daily life (r = 0.04, p = 0.74). Multiple regression analyses showed associations between higher fatigue on FSS and greater breathlessness on Dyspnoea-12 (standardised beta = 0.546, p < 0.001) and lower daily steps (standardised beta = -0.188, p = 0.02).
Conclusion: Dyspnoea and physical activity are associated with fatigue in fILD. Exertional desaturation does not appear to contribute to fatigue in this group.
期刊介绍：
Respirology is a journal of international standing, publishing peer-reviewed articles of scientific excellence in clinical and clinically-relevant experimental respiratory biology and disease. Fields of research include immunology, intensive and critical care, epidemiology, cell and molecular biology, pathology, pharmacology, physiology, paediatric respiratory medicine, clinical trials, interventional pulmonology and thoracic surgery.
The Journal aims to encourage the international exchange of results and publishes papers in the following categories: Original Articles, Editorials, Reviews, and Correspondences.
Respirology is the preferred journal of the Thoracic Society of Australia and New Zealand, has been adopted as the preferred English journal of the Japanese Respiratory Society and the Taiwan Society of Pulmonary and Critical Care Medicine and is an official journal of the World Association for Bronchology and Interventional Pulmonology.
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