Jiali Lei, Catherine W Gillespie, Serena Santoni, Jam Suba, Niranjan Kanesa-Thasan, Ajoke Sobanjo-Ter Meulen
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引用次数: 0
Abstract
Background: The epidemiologic landscape for human metapneumovirus (hMPV), a respiratory pathogen, is poorly characterized, particularly among older adults.
Methods: Leveraging the latest estimates of lower respiratory infection (LRI) incidence from the Global Burden of Disease Study 2021 and meta-analyzed findings from a systematic literature review, we quantified the incidence of LRI with hMPV in 10 high-income locations among older adults in the most recent prepandemic year (2019): Canada, Chile, France, Germany, New Zealand, Netherlands, Italy, Spain, United Kingdom, and United States.
Results: The systematic literature review identified 21 studies with data on the percentage of LRI episodes associated with hMPV in adults aged ≥60 years in the targeted locations. Combining the meta-analyzed percentage of LRI cases associated with hMPV from these studies (7.0%; 95% CI, 5.4%-9.1%) with age-, sex-, and location-specific estimates of LRI incidence from the Global Burden of Disease Study 2021, we estimated that hMPV incidence rates per 100 000 in 2019 among adults aged ≥60 ranged from 185.7 (95% uncertainty interval, 134.7-251.1) in Italy to 462.1 (333.1-628.2) in the United States.
Conclusions: Overall, our literature review, meta-analysis, and modeling study confirm a significant burden of hMPV-associated LRI in older adults. This work fills a critical evidence gap in the epidemiologic landscape of hMPV and yields actionable estimates to inform vaccine development strategies and other strategic initiatives. Future inclusion of hMPV in routine surveillance would enable more comprehensive estimates of hMPV incidence and outcomes.
背景：人类偏肺病毒（hMPV）是一种呼吸道病原体，其流行病学特征尚不明确，特别是在老年人中。方法：利用《2021年全球疾病负担研究》（Global Burden of Disease Study 2021）对下呼吸道感染（LRI）发病率的最新估计和系统性文献综述的meta分析结果，我们量化了最近一年（2019年）10个高收入地区老年人中hMPV合并下呼吸道感染的发病率：加拿大、智利、法国、德国、新西兰、荷兰、意大利、西班牙、英国和美国。结果：系统文献综述确定了21项研究，这些研究的数据是针对目标地区年龄≥60岁的成人中与hMPV相关的LRI发作百分比。结合这些研究中与hMPV相关的LRI病例的荟萃分析百分比(7.0%；根据2021年全球疾病负担研究中年龄、性别和地点特异性LRI发病率估计，我们估计2019年60岁以上成年人的hMPV发病率从意大利的185.7（95%不确定区间，134.7-251.1）到美国的462.1（333.1-628.2）不等。结论：总的来说，我们的文献综述、荟萃分析和模型研究证实了老年人hmpv相关的LRI的显著负担。这项工作填补了hMPV流行病学领域的关键证据空白，并产生了可操作的估计，为疫苗开发战略和其他战略举措提供信息。今后将hMPV纳入常规监测将有助于更全面地估计hMPV的发病率和结果。
期刊介绍：
Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.
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