Yiyang Chen, Zhenghong Liu, Bin Zheng, Chenkai Wang, Xintao Hua, Pu Zhang, Dahong Zhang
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引用次数: 0
Abstract
Topical administration provides direct way for nanoparticles (NPs) to reach the tumour surface, inducing a more localised and direct therapeutic effect than what intravenous therapy can do and meanwhile guaranteeing higher biosafety. By leveraging the unique surface structure of tumours, these particles undergo intracavity diffusion and afterwards targeted transport into the tumour tissue, which is termed as the enhanced surface permeability and retention (ESPR) effect. Importantly, the ESPR effect of intracavity nanoparticles via topical administration does not rely on tumour-targeted ligand-receptor interactions. In this review, the current clinical status of topical administration-based therapy is updated, the mechanism of the ESPR effect is elucidated and how to modulate the ESPR effect is summarised.
期刊介绍：
Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs.
Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.
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