Research progress of Mendelian randomization analysis for glaucoma etiology.

IF 1.9 4区 医学 Q2 OPHTHALMOLOGY
International journal of ophthalmology Pub Date : 2025-07-18 eCollection Date: 2025-01-01 DOI:10.18240/ijo.2025.07.23
Jiao-Man Wang, Yin-Wei Song, Jing-Jing Su, Li-Cheng Fu, Di Gong, Ping Guo, Wei-Hua Yang
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引用次数: 0

Abstract

In recent years, Mendelian randomization (MR) has been increasingly utilized, leveraging genetic variants as instrumental variables. This approach significantly mitigates confounder effects and reverse causation, precisely clarifying the causal links between exposures and outcomes. MR's unique advantages have made it instrumental in medicine, especially in elucidating glaucoma's etiology. It facilitates the identification of potential risk factors, laying the groundwork for developing preventative and therapeutic strategies against glaucoma. Recent MR research has delved into diverse potential glaucoma risk factors, including behavioral habits, metabolic profiles, and their causative linkage to the disease. This review encapsulates MR's analysis in glaucoma etiology, heralding new avenues for understanding underlying mechanisms and establishing causality.

青光眼病因的孟德尔随机化分析研究进展。
近年来,孟德尔随机化(MR)越来越多地利用遗传变异作为工具变量。这种方法显著减轻了混杂效应和反向因果关系,准确地阐明了暴露与结果之间的因果关系。磁共振成像的独特优势使其在医学上发挥了重要作用,特别是在阐明青光眼的病因方面。它有助于识别潜在的危险因素,为制定青光眼的预防和治疗策略奠定基础。最近的MR研究深入探讨了各种潜在的青光眼危险因素,包括行为习惯、代谢特征及其与该病的致病关系。这篇综述概括了MR在青光眼病因学中的分析,预示着理解潜在机制和建立因果关系的新途径。
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来源期刊
CiteScore
2.50
自引率
7.10%
发文量
3141
审稿时长
4-8 weeks
期刊介绍: · International Journal of Ophthalmology-IJO (English edition) is a global ophthalmological scientific publication and a peer-reviewed open access periodical (ISSN 2222-3959 print, ISSN 2227-4898 online). This journal is sponsored by Chinese Medical Association Xi’an Branch and obtains guidance and support from WHO and ICO (International Council of Ophthalmology). It has been indexed in SCIE, PubMed, PubMed-Central, Chemical Abstracts, Scopus, EMBASE , and DOAJ. IJO JCR IF in 2017 is 1.166. IJO was established in 2008, with editorial office in Xi’an, China. It is a monthly publication. General Scientific Advisors include Prof. Hugh Taylor (President of ICO); Prof.Bruce Spivey (Immediate Past President of ICO); Prof.Mark Tso (Ex-Vice President of ICO) and Prof.Daiming Fan (Academician and Vice President, Chinese Academy of Engineering. International Scientific Advisors include Prof. Serge Resnikoff (WHO Senior Speciatist for Prevention of blindness), Prof. Chi-Chao Chan (National Eye Institute, USA) and Prof. Richard L Abbott (Ex-President of AAO/PAAO) et al. Honorary Editors-in-Chief: Prof. Li-Xin Xie(Academician of Chinese Academy of Engineering/Honorary President of Chinese Ophthalmological Society); Prof. Dennis Lam (President of APAO) and Prof. Xiao-Xin Li (Ex-President of Chinese Ophthalmological Society). Chief Editor: Prof. Xiu-Wen Hu (President of IJO Press). Editors-in-Chief: Prof. Yan-Nian Hui (Ex-Director, Eye Institute of Chinese PLA) and Prof. George Chiou (Founding chief editor of Journal of Ocular Pharmacology & Therapeutics). Associate Editors-in-Chief include: Prof. Ning-Li Wang (President Elect of APAO); Prof. Ke Yao (President of Chinese Ophthalmological Society) ; Prof.William Smiddy (Bascom Palmer Eye instituteUSA) ; Prof.Joel Schuman (President of Association of University Professors of Ophthalmology,USA); Prof.Yizhi Liu (Vice President of Chinese Ophtlalmology Society); Prof.Yu-Sheng Wang (Director of Eye Institute of Chinese PLA); Prof.Ling-Yun Cheng (Director of Ocular Pharmacology, Shiley Eye Center, USA). IJO accepts contributions in English from all over the world. It includes mainly original articles and review articles, both basic and clinical papers. Instruction is Welcome Contribution is Welcome Citation is Welcome Cooperation organization International Council of Ophthalmology(ICO), PubMed, PMC, American Academy of Ophthalmology, Asia-Pacific, Thomson Reuters, The Charlesworth Group, Crossref,Scopus,Publons, DOAJ etc.
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