Gonçalo Cavaco Tardão, Pedro Carreira, Filipe Moraes, Rita Carreira, Tomás Loureiro, Ana Vide Escada, Maria José Santos, Ana Melo Cardoso, Nuno Campos
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引用次数: 0
Abstract
Aim: To characterize a Portuguese population of patients with juvenile idiopathic arthritis (JIA) and to evaluate possible associations between clinical factors and ocular involvement.
Methods: Patients diagnosed with JIA in the previous 20y in Hospital Garcia de Orta were included. Data were assessed from Reuma.pt database. Associations between demographic (age and sex), clinical (articular involvement, extra-articular manifestations, biological therapy), laboratory data [anti-nuclear antibodies, anti-cyclic citrullinated peptide (CCP) antibodies, rheumatoid factor, human leukocyte antigen B27 (HLA-B27), C-reactive protein, erythrocyte sedimentation rate] and ocular involvement were assessed. Statistical analysis was performed using Chi-square for categorical variables and Mann-Whitney test for continuous variables.
Results: Totally 91 patients were included, 11 (12%) with previous episodes of uveitis. There was a statistically significant preponderance of early age at JIA diagnosis (mean 4.73 vs 9.58y, P=0.008), antinuclear antibodies positivity (P=0.01), and oligoarticular subtype (P=0.04) in the Juvenile idiopathic arthritis-associated uveitis (JIA-U) group. Ocular complications occurred in 36.4% of patients (n=4): cataracts (n=2), band keratopathy (n=1) and posterior synechiae (n=1). The occurrence of complications was corelated with a shorter period between JIA diagnosis and the first JIA-U episode (mean 0.67 vs 4.88y, P=0.012) but not with age at JIA diagnosis or articular involvement. There was erythrocyte sedimentation rate elevation in the 12mo preceding uveitis (mean 40.5 mm/h, range 13-83).
Conclusion: The occurrence of JIA-U shortly after JIA diagnosis is shown to be a potential risk factor for ocular complications.
目的：描述葡萄牙青少年特发性关节炎（JIA）患者的特征，并评估临床因素与眼部受累之间的可能关联。方法：纳入Garcia de Orta医院过去20年诊断为JIA的患者。数据来自Reuma.pt数据库。评估人口统计学（年龄和性别）、临床（关节受累、关节外表现、生物治疗）、实验室数据（抗核抗体、抗环氨酸肽（CCP）抗体、类风湿因子、人白细胞抗原B27 （HLA-B27）、c反应蛋白、红细胞沉降率）与眼部受累之间的关系。分类变量采用卡方检验，连续变量采用Mann-Whitney检验。结果：共纳入91例患者，其中11例（12%）既往有葡萄膜炎发作。幼年特发性关节炎相关性葡萄膜炎（JIA- u）组中，JIA诊断年龄较早（平均4.73 vs 9.58， P=0.008）、抗核抗体阳性（P=0.01）、寡关节亚型（P=0.04）的优势具有统计学意义。36.4%的患者（n=4）发生眼部并发症：白内障（n=2）、带状角膜病变（n=1）和后粘连（n=1）。并发症的发生与JIA诊断与首次JIA- u发作之间较短的时间相关（平均0.67 vs 4.88， P=0.012），但与JIA诊断时的年龄或关节受累无关。葡萄膜炎前12个月红细胞沉降率升高（平均40.5 mm/h，范围13-83）。结论：JIA诊断后不久出现JIA- u是发生眼部并发症的潜在危险因素。
期刊介绍：
· International Journal of Ophthalmology-IJO (English edition) is a global ophthalmological scientific publication
and a peer-reviewed open access periodical (ISSN 2222-3959 print, ISSN 2227-4898 online).
This journal is sponsored by Chinese Medical Association Xi’an Branch and obtains guidance and support from
WHO and ICO (International Council of Ophthalmology). It has been indexed in SCIE, PubMed,
PubMed-Central, Chemical Abstracts, Scopus, EMBASE , and DOAJ. IJO JCR IF in 2017 is 1.166.
IJO was established in 2008, with editorial office in Xi’an, China. It is a monthly publication. General Scientific
Advisors include Prof. Hugh Taylor (President of ICO); Prof.Bruce Spivey (Immediate Past President of ICO);
Prof.Mark Tso (Ex-Vice President of ICO) and Prof.Daiming Fan (Academician and Vice President,
Chinese Academy of Engineering.
International Scientific Advisors include Prof. Serge Resnikoff (WHO Senior Speciatist for Prevention of
blindness), Prof. Chi-Chao Chan (National Eye Institute, USA) and Prof. Richard L Abbott (Ex-President of
AAO/PAAO) et al.
Honorary Editors-in-Chief: Prof. Li-Xin Xie(Academician of Chinese Academy of
Engineering/Honorary President of Chinese Ophthalmological Society); Prof. Dennis Lam (President of APAO) and
Prof. Xiao-Xin Li (Ex-President of Chinese Ophthalmological Society).
Chief Editor: Prof. Xiu-Wen Hu (President of IJO Press).
Editors-in-Chief: Prof. Yan-Nian Hui (Ex-Director, Eye Institute of Chinese PLA) and
Prof. George Chiou (Founding chief editor of Journal of Ocular Pharmacology & Therapeutics).
Associate Editors-in-Chief include:
Prof. Ning-Li Wang (President Elect of APAO);
Prof. Ke Yao (President of Chinese Ophthalmological Society) ;
Prof.William Smiddy (Bascom Palmer Eye instituteUSA) ;
Prof.Joel Schuman (President of Association of University Professors of Ophthalmology,USA);
Prof.Yizhi Liu (Vice President of Chinese Ophtlalmology Society);
Prof.Yu-Sheng Wang (Director of Eye Institute of Chinese PLA);
Prof.Ling-Yun Cheng (Director of Ocular Pharmacology, Shiley Eye Center, USA).
IJO accepts contributions in English from all over the world. It includes mainly original articles and review articles,
both basic and clinical papers.
Instruction is Welcome Contribution is Welcome Citation is Welcome
Cooperation organization
International Council of Ophthalmology(ICO), PubMed, PMC, American Academy of Ophthalmology, Asia-Pacific, Thomson Reuters, The Charlesworth Group, Crossref,Scopus,Publons, DOAJ etc.
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