Correlation between corneal biomechanical and tomographic parameters in cataract patients.

IF 1.8 4区 医学 Q2 OPHTHALMOLOGY
International journal of ophthalmology Pub Date : 2025-07-18 eCollection Date: 2025-01-01 DOI:10.18240/ijo.2025.07.11
Jia-Xi Li, Yi-He Liu, Yu-Shi Liu, Zi-Yuan Liu, Xue-Min Li
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引用次数: 0

Abstract

Aim: To investigate the relationship between preoperative corneal biomechanical properties and corneal tomographic properties in cataract patients.

Methods: The study consisted of 59 eyes of 30 participants who were diagnosed as cataract in Peking University Third Hospital between September 2019 and November 2019. Stepwise multivariable linear regression analysis was calculated to determine the relationship between corneal biomechanical parameters and tomographic parameters. The patients were classified into three groups of with the rule (WTR) astigmatism, against the rule astigmatism and oblique astigmatism. And the differences in corneal parameters among different groups were compared.

Results: There were significant differences in the first applanation time (A1T), the first applanation length (A1L), corneal velocity during the first applanation (Vin), the second applanation time (A2T), highest concavity (HC) radius, displacement amount (DA), DA ratio, stiffness parameter A1 (SPA1) and integrated radius (IR) between oblique astigmatism patients and the other two groups. Total corneal steep meridian (K2) was negatively associated with A1L, A1T and corneal velocity during the second applanation (Vout). Patients with higher anterior corneal curvature had lower HC radius and central corneal thickness (CCT; P=0.001 and 0.006, respectively), while the Ambrosio relational thickness to the horizontal profile (ARTh) was higher than those with lower anterior corneal curvature (P=0.009).

Conclusion: The study reveals that the elasticity of corneal collagen fibers is greater, but the viscoelasticity of cornea is smaller in patients with oblique astigmatism. There is no significant difference in ARTh between patients with different types of astigmatism, that is, the corneal biomechanical specificity of oblique astigmatism group is probably not caused by corneal thickness. Moreover, we find patients with higher anterior corneal curvature has lower HC radius and CCT but higher ARTh than those with lower anterior corneal curvature.

白内障患者角膜生物力学与层析成像参数的相关性研究。
目的:探讨白内障患者术前角膜生物力学特性与角膜层析成像特性的关系。方法:该研究包括2019年9月至2019年11月在北京大学第三医院诊断为白内障的30名参与者的59只眼睛。计算逐步多变量线性回归分析,确定角膜生物力学参数与层析成像参数之间的关系。将患者分为顺势散光、逆势散光和斜向散光三组。比较各组角膜参数的差异。结果:斜向散光患者与其他两组患者在第一次压平时间(A1T)、第一次压平长度(A1L)、第一次压平时角膜速度(Vin)、第二次压平时间(A2T)、最大凹度(HC)半径、位移量(DA)、DA比、刚度参数A1 (SPA1)、综合半径(IR)等方面均存在显著差异。角膜总陡经线(K2)与第二次压平时A1L、A1T和角膜速度呈负相关(Vout)。角膜前曲率较高的患者HC半径和角膜中央厚度(CCT)较低;P=0.001和0.006),而Ambrosio水平剖面相关厚度(ARTh)高于角膜前曲率较低的患者(P=0.009)。结论:斜向散光患者角膜胶原纤维弹性较大,而角膜粘弹性较小。不同散光类型患者的ARTh无明显差异,即斜向散光组角膜生物力学特异性可能不是由角膜厚度引起的。此外,我们发现角膜前曲率较高的患者比角膜前曲率较低的患者HC半径和CCT较低,但ARTh较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.50
自引率
7.10%
发文量
3141
审稿时长
4-8 weeks
期刊介绍: · International Journal of Ophthalmology-IJO (English edition) is a global ophthalmological scientific publication and a peer-reviewed open access periodical (ISSN 2222-3959 print, ISSN 2227-4898 online). This journal is sponsored by Chinese Medical Association Xi’an Branch and obtains guidance and support from WHO and ICO (International Council of Ophthalmology). It has been indexed in SCIE, PubMed, PubMed-Central, Chemical Abstracts, Scopus, EMBASE , and DOAJ. IJO JCR IF in 2017 is 1.166. IJO was established in 2008, with editorial office in Xi’an, China. It is a monthly publication. General Scientific Advisors include Prof. Hugh Taylor (President of ICO); Prof.Bruce Spivey (Immediate Past President of ICO); Prof.Mark Tso (Ex-Vice President of ICO) and Prof.Daiming Fan (Academician and Vice President, Chinese Academy of Engineering. International Scientific Advisors include Prof. Serge Resnikoff (WHO Senior Speciatist for Prevention of blindness), Prof. Chi-Chao Chan (National Eye Institute, USA) and Prof. Richard L Abbott (Ex-President of AAO/PAAO) et al. Honorary Editors-in-Chief: Prof. Li-Xin Xie(Academician of Chinese Academy of Engineering/Honorary President of Chinese Ophthalmological Society); Prof. Dennis Lam (President of APAO) and Prof. Xiao-Xin Li (Ex-President of Chinese Ophthalmological Society). Chief Editor: Prof. Xiu-Wen Hu (President of IJO Press). Editors-in-Chief: Prof. Yan-Nian Hui (Ex-Director, Eye Institute of Chinese PLA) and Prof. George Chiou (Founding chief editor of Journal of Ocular Pharmacology & Therapeutics). Associate Editors-in-Chief include: Prof. Ning-Li Wang (President Elect of APAO); Prof. Ke Yao (President of Chinese Ophthalmological Society) ; Prof.William Smiddy (Bascom Palmer Eye instituteUSA) ; Prof.Joel Schuman (President of Association of University Professors of Ophthalmology,USA); Prof.Yizhi Liu (Vice President of Chinese Ophtlalmology Society); Prof.Yu-Sheng Wang (Director of Eye Institute of Chinese PLA); Prof.Ling-Yun Cheng (Director of Ocular Pharmacology, Shiley Eye Center, USA). IJO accepts contributions in English from all over the world. It includes mainly original articles and review articles, both basic and clinical papers. Instruction is Welcome Contribution is Welcome Citation is Welcome Cooperation organization International Council of Ophthalmology(ICO), PubMed, PMC, American Academy of Ophthalmology, Asia-Pacific, Thomson Reuters, The Charlesworth Group, Crossref,Scopus,Publons, DOAJ etc.
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