Gut Microbiota and Bipolar Disorder: Advances in Translational Applications.

Abstract

Bipolar disorder is a severe, recurrent affective disorder that imposes significant pain and burden on both the patients themselves and the social economy. Recent studies have indicated the involvement of intestinal flora in emotional regulation, as well as its close association with the occurrence and progression of diseases such as bipolar disorder. Therefore, conducting comprehensive research on the impact of intestinal microflora and the "gut-brain axis" on bipolar disorder becomes imperative, offering novel insights into its etiology, diagnosis, and treatment options. Consequently, this article provides an overview of the role and potential mechanisms underlying intestinal microbiota in bipolar disorder.