Association Between Serum Folic Acid Levels and Type 2 Diabetes Mellitus in Overweight or Obese Patients: A Retrospective Study.

IF 3 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-07-15 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S521273

Yaji Dai, Mingfei Guo, Jianglei Xiong, Lei Jiang

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Abstract

Purpose: The relationship between folic acid (FA) levels and type 2 diabetes mellitus (T2DM) with overweight or obesity remains uncertain. This study aimed to further investigate the relationship between them.

Methods: A retrospective study was conducted on 149 patients, comprising 64 patients with T2DM and normal weight and 85 patients with T2DM and overweight or obese status.

Results: Our findings revealed significantly lower levels of FA and neutrophil-to-lymphocyte ratio (NLR) in overweight/obese T2DM patients compared to their normal-BMI counterparts (P < 0.001). The overweight/obese cohort exhibited elevated metabolic parameters, including fasting C-peptide, serum uric acid, total cholesterol (TC), triglycerides (TG), and very low-density lipoprotein cholesterol (VLDL-C) levels (P < 0.05). Notably, correlation analysis demonstrated a significant positive association between FA levels and both age (r = 0.341, P < 0.001), diabetes duration (r = 0.278, P = 0.001), and NLR (r = 0.212, P = 0.009). Conversely, inverse correlations were observed between FA levels and C-peptide (r = -0.240, P = 0.004), TG (r = -0.254, P < 0.001), and VLDL-C (r = -0.271, P = 0.001).

Conclusion: This research found that FA levels were significantly associated with T2DM in individuals who were overweight or obese.

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超重或肥胖患者血清叶酸水平与2型糖尿病的关系：一项回顾性研究

目的：叶酸（FA）水平与2型糖尿病（T2DM）合并超重或肥胖之间的关系尚不确定。本研究旨在进一步探讨两者之间的关系。方法：对149例患者进行回顾性研究，其中体重正常的T2DM患者64例，超重或肥胖的T2DM患者85例。结果：我们的研究结果显示，与bmi正常的T2DM患者相比，超重/肥胖T2DM患者的FA和中性粒细胞/淋巴细胞比率（NLR）水平显著降低（P < 0.001）。超重/肥胖组的代谢参数升高，包括空腹c肽、血清尿酸、总胆固醇（TC）、甘油三酯（TG）和极低密度脂蛋白胆固醇（VLDL-C）水平（P < 0.05）。值得注意的是，相关分析显示FA水平与年龄（r = 0.341, P < 0.001）、糖尿病病程（r = 0.278, P = 0.001）和NLR （r = 0.212, P = 0.009）呈正相关。相反，FA水平与c肽（r = -0.240, P = 0.004）、TG （r = -0.254, P < 0.001）和VLDL-C （r = -0.271, P = 0.001）呈负相关。结论：本研究发现，在超重或肥胖的个体中，FA水平与2型糖尿病显著相关。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.