BCRT-DETR: A Lightweight Blood Cell Detection Transformer Model for Enhanced Medical Diagnostics.

IF 2.7 4区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Xi Chen, Guohui Wang
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引用次数: 0

Abstract

In the biomedical field, the detection of microscopic images of blood cells is crucial for diagnosing of blood-related diseases. To enhance accuracy and real-time performance, we developed a blood cell real-time detection transformer (BCRT-DETR) to improve detection efficiency. A dynamic alignment integration backbone network (DAIBN) was introduced to address the spatial differences in features from diverse sources during multi-backbone information fusion. Additionally, a multi-scale parallel aggregation splicing (MPAS) module was integrated into the neck component to mitigate missed detections during cell feature extraction. The integration of high- and low-frequency (HiLo) attention with the attention-based intra-scale feature interaction (AIFI) module to form AIFI-HiLo effectively overcame the model's previous limitation of concentrating on regions with cellular density. The introduction of the retentive meet transformer block (RMT_Block) in the neck component further optimized the computational complexity, thereby increasing the detection speed. The experimental results indicated that, compared with the recent transformer-based real-time detection model, RT-DETR, BCRT-DETR achieved significant efficiency improvements with reductions of 33.8%, 51.1%, and 34.1% in parameters, giga floating-point operations per second (GFLOPs), and model size, respectively. Simultaneously, BCRT-DETR improved mAP50 and mAP50:95 by 0.8% and 1.6%, respectively, with mAP50 reaching 96.8%. Furthermore, BCRT-DETR demonstrated exceptional generalization capabilities across the blood cell detection, blood cell count and detection, and complete blood count datasets. Our model provides reliable technical support and offers innovative solutions for automated medical diagnosis.

BCRT-DETR:用于增强医疗诊断的轻量级血细胞检测变压器模型。
在生物医学领域,血液细胞显微图像的检测对于血液相关疾病的诊断至关重要。为了提高准确性和实时性,我们开发了一种血细胞实时检测变压器(BCRT-DETR)来提高检测效率。为了解决多主干网信息融合过程中不同来源特征的空间差异,提出了一种动态对准集成主干网(DAIBN)。此外,颈部组件集成了一个多尺度平行聚集剪接(MPAS)模块,以减轻细胞特征提取过程中的遗漏检测。将高低频(HiLo)注意与基于注意的尺度内特征交互(AIFI)模块相结合,形成AIFI-HiLo,有效克服了以往模型集中于具有细胞密度区域的局限性。颈部组件中引入了保持满足变压器块(RMT_Block),进一步优化了计算复杂度,从而提高了检测速度。实验结果表明,与目前基于变压器的实时检测模型相比,RT-DETR、BCRT-DETR在参数、每秒千兆浮点运算(GFLOPs)和模型尺寸方面分别降低了33.8%、51.1%和34.1%,显著提高了检测效率。同时,BCRT-DETR分别提高了mAP50和mAP50:95的0.8%和1.6%,mAP50达到96.8%。此外,BCRT-DETR在血细胞检测、血细胞计数和检测以及完整血细胞计数数据集方面表现出了卓越的泛化能力。我们的模型为自动化医疗诊断提供可靠的技术支持和创新的解决方案。
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来源期刊
Biotechnology and applied biochemistry
Biotechnology and applied biochemistry 工程技术-生化与分子生物学
CiteScore
6.00
自引率
7.10%
发文量
117
审稿时长
3 months
期刊介绍: Published since 1979, Biotechnology and Applied Biochemistry is dedicated to the rapid publication of high quality, significant research at the interface between life sciences and their technological exploitation. The Editors will consider papers for publication based on their novelty and impact as well as their contribution to the advancement of medical biotechnology and industrial biotechnology, covering cutting-edge research in synthetic biology, systems biology, metabolic engineering, bioengineering, biomaterials, biosensing, and nano-biotechnology.
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