Xinyu Li, Lisa W. C. Au, Huifen Hao, Yingying Li, Xiuju Gao, Junqiang Yan, Raymond K. Y. Tong, Wutao Lou
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引用次数: 0
Abstract
Menstrual-related migraine (MRM) is a neurovascular disorder associated with decreased sex hormone levels. The menstrual cycle influences both cerebrovascular function and functional brain connectivity, with accumulating evidence linking migraine to altered connectivity, particularly in the insula. However, the neuropathological mechanisms underlying MRM during the menstrual cycle remain poorly understood. In this longitudinal study, 36 MRM patients and 29 healthy controls were recruited. Sex hormone levels and resting-state functional magnetic resonance imaging (fMRI) were collected during both the late-follicular phase (LFP) and the perimenstrual phase (PMP). Neurovascular function was assessed using voxel-wise hemodynamic response function (HRF) parameters. The subregions of insula-to-whole-brain phase synchronization were estimated using the HRF variations corrected phase information. Our results showed that hormone level decreases from the LFP to the PMP modulated HRF response heights. Changes in the HRF width were reversed between MRM patients and controls, with hormone fluctuations particularly affecting the superior temporal gyrus in the MRM group. Additionally, MRM patients exhibited increased insular phase synchronization in the LFP and reduced synchronization in the PMP. These findings suggest that menstrual cycle-related hormone fluctuations contribute to dysregulated neurovascular coupling in MRM. The reduced insular phase synchronization in the PMP may not be directly driven by these hormone changes.
期刊介绍:
Human Brain Mapping publishes peer-reviewed basic, clinical, technical, and theoretical research in the interdisciplinary and rapidly expanding field of human brain mapping. The journal features research derived from non-invasive brain imaging modalities used to explore the spatial and temporal organization of the neural systems supporting human behavior. Imaging modalities of interest include positron emission tomography, event-related potentials, electro-and magnetoencephalography, magnetic resonance imaging, and single-photon emission tomography. Brain mapping research in both normal and clinical populations is encouraged.
Article formats include Research Articles, Review Articles, Clinical Case Studies, and Technique, as well as Technological Developments, Theoretical Articles, and Synthetic Reviews. Technical advances, such as novel brain imaging methods, analyses for detecting or localizing neural activity, synergistic uses of multiple imaging modalities, and strategies for the design of behavioral paradigms and neural-systems modeling are of particular interest. The journal endorses the propagation of methodological standards and encourages database development in the field of human brain mapping.