Engineering next-generation smart delivery materials for dentistry

IF 15.9 1区化学 Q1 CHEMISTRY, PHYSICAL

Advances in Colloid and Interface Science Pub Date : 2025-07-16 DOI:10.1016/j.cis.2025.103607

Sumanta Ghosh , Chao Liang , Sang Jin Lee , Wei Qiao

{"title":"Engineering next-generation smart delivery materials for dentistry","authors":"Sumanta Ghosh , Chao Liang , Sang Jin Lee , Wei Qiao","doi":"10.1016/j.cis.2025.103607","DOIUrl":null,"url":null,"abstract":"<div><div>Over the last two decades, the healthcare field has witnessed exponential growth in the applications of stimuli-responsive biomaterials for diverse therapeutic purposes. This has led to the development of numerous smart dental biomaterials tailored for the precise and on-demand delivery of therapeutic agents. By leveraging the specific exogenous and endogenous stimuli, these smart materials fine-tune their physicochemical properties to improve the clinical efficacy of the therapeutic agents and mitigate their side effects. This review systemically examines the design and objectives of the smart biomaterials platforms specifically for dental and associated soft tissue. Additionally, we comprehensively summarize various smart biomaterials-based delivery platforms, categorized by the nature of the stimuli, including pH, enzyme, temperature, light, ultrasound, electricity, and pressure. Furthermore, this review discusses several newly developed smart platforms utilized in different dental conditions, with a particular focus on those undergoing clinical trials. This review aims to provide an overview of the state-of-the-art smart drug delivery systems in dentistry and offer insights into developing next-generation platforms to address various clinical needs, such as infection eradication, inflammation modulation, tissue regeneration, and immunotherapy.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"344 ","pages":"Article 103607"},"PeriodicalIF":15.9000,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Colloid and Interface Science","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0001868625002180","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Over the last two decades, the healthcare field has witnessed exponential growth in the applications of stimuli-responsive biomaterials for diverse therapeutic purposes. This has led to the development of numerous smart dental biomaterials tailored for the precise and on-demand delivery of therapeutic agents. By leveraging the specific exogenous and endogenous stimuli, these smart materials fine-tune their physicochemical properties to improve the clinical efficacy of the therapeutic agents and mitigate their side effects. This review systemically examines the design and objectives of the smart biomaterials platforms specifically for dental and associated soft tissue. Additionally, we comprehensively summarize various smart biomaterials-based delivery platforms, categorized by the nature of the stimuli, including pH, enzyme, temperature, light, ultrasound, electricity, and pressure. Furthermore, this review discusses several newly developed smart platforms utilized in different dental conditions, with a particular focus on those undergoing clinical trials. This review aims to provide an overview of the state-of-the-art smart drug delivery systems in dentistry and offer insights into developing next-generation platforms to address various clinical needs, such as infection eradication, inflammation modulation, tissue regeneration, and immunotherapy.

Abstract Image

查看原文本刊更多论文

设计用于牙科的下一代智能输送材料

在过去的二十年里，医疗保健领域见证了刺激反应生物材料在各种治疗目的中的应用呈指数级增长。这导致了许多智能牙科生物材料的发展，为治疗剂的精确和按需输送量身定制。通过利用特定的外源性和内源性刺激，这些智能材料微调其物理化学性质，以提高治疗剂的临床疗效并减轻其副作用。本综述系统地研究了智能生物材料平台的设计和目标，特别是针对牙科和相关软组织。此外，我们全面总结了各种基于智能生物材料的递送平台，根据刺激的性质进行分类，包括pH值、酶、温度、光、超声、电和压力。此外，本综述讨论了几种新开发的智能平台，用于不同的牙科条件，特别关注那些正在进行临床试验。本综述旨在概述牙科领域最先进的智能给药系统，并为开发下一代平台提供见解，以满足各种临床需求，如感染根除、炎症调节、组织再生和免疫治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Advances in Colloid and Interface Science 化学-物理化学

CiteScore

28.50

自引率

2.60%

发文量

175

审稿时长

31 days

期刊介绍： "Advances in Colloid and Interface Science" is an international journal that focuses on experimental and theoretical developments in interfacial and colloidal phenomena. The journal covers a wide range of disciplines including biology, chemistry, physics, and technology. The journal accepts review articles on any topic within the scope of colloid and interface science. These articles should provide an in-depth analysis of the subject matter, offering a critical review of the current state of the field. The author's informed opinion on the topic should also be included. The manuscript should compare and contrast ideas found in the reviewed literature and address the limitations of these ideas. Typically, the articles published in this journal are written by recognized experts in the field.