Mohammad Saim Raza, K. M. Roshani, Rama Krishna Peddinti
{"title":"(4 + 3) Annulation of Enone-Tethered Indoles with α-Alkylidene Succinimides: Access to Seven-Membered Azepino[3,2,1-hi]Indole Scaffolds","authors":"Mohammad Saim Raza, K. M. Roshani, Rama Krishna Peddinti","doi":"10.1039/d5cc02885j","DOIUrl":null,"url":null,"abstract":"We have developed a straightforward synthesis of azepino[3,2,1-hi]indole architectures having four contiguous chiral carbons as single diastereomers. This metal-free protocol between indole-enones and alkylidene succinimides proceeds efficiently under ambient conditions, demonstrating a broad scope in good to excellent yields. The feasibility of the current methodology was illustrated by one-pot, gram-scale synthesis and further modifications.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"675 1","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5cc02885j","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
We have developed a straightforward synthesis of azepino[3,2,1-hi]indole architectures having four contiguous chiral carbons as single diastereomers. This metal-free protocol between indole-enones and alkylidene succinimides proceeds efficiently under ambient conditions, demonstrating a broad scope in good to excellent yields. The feasibility of the current methodology was illustrated by one-pot, gram-scale synthesis and further modifications.
期刊介绍:
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