Metabolic engineering of Micromonospora for exploring useful natural products and phytobiotic interaction

IF 6.8 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Metabolic engineering Pub Date : 2025-07-20 DOI:10.1016/j.ymben.2025.07.005

Boncheol Gu, Jimin Lee, Duck Gyun Kim, Yu-jin Cha, Min-Kyu Oh

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Abstract

Micromonospora, a genus within the Actinobacteria phylum, is recognized for its prolific production of bioactive secondary metabolites. It has important applications in the pharmaceutical, biotechnology, and agricultural fields. Micromonospora is renowned for generating antibiotics, anticancer agents, immunosuppressants, and plant growth-promoting compounds, making it a primary subject in natural product research. Advances in genome sequencing and mining technologies have revealed numerous biosynthetic gene clusters, many of which remain unexplored, underscoring their vast, untapped biosynthetic potential. This review presents an in-depth summary of the role of Micromonospora in the discovery of novel bioactive compounds and their biotechnological and industrial applications. Furthermore, we discuss the plant-microbe interactions of Micromonospora, consolidating current knowledge from its historical discovery to recent genomic insights, and outlines future research directions and challenges for optimizing the biotechnological potential of this promising yet underexploited microbial resource.

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利用小单孢子菌代谢工程探索有用的天然产物和植物共生相互作用

小单孢子菌是放线菌门中的一个属，以其多产的生物活性次生代谢物而闻名。它在制药、生物技术和农业领域有着重要的应用。小单孢子菌以产生抗生素、抗癌剂、免疫抑制剂和植物生长促进化合物而闻名，使其成为天然产物研究的主要课题。基因组测序和挖掘技术的进步揭示了许多生物合成基因簇，其中许多仍未被探索，强调了它们巨大的、未开发的生物合成潜力。本文综述了小单孢子菌在新型生物活性化合物的发现及其生物技术和工业应用中的作用。此外，我们讨论了小单孢菌的植物与微生物的相互作用，从其历史发现到最近的基因组见解，巩固了当前的知识，并概述了未来的研究方向和挑战，以优化这一有前途但尚未开发的微生物资源的生物技术潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolic engineering 工程技术-生物工程与应用微生物

CiteScore

15.60

自引率

6.00%

发文量

140

审稿时长

44 days

期刊介绍： Metabolic Engineering (MBE) is a journal that focuses on publishing original research papers on the directed modulation of metabolic pathways for metabolite overproduction or the enhancement of cellular properties. It welcomes papers that describe the engineering of native pathways and the synthesis of heterologous pathways to convert microorganisms into microbial cell factories. The journal covers experimental, computational, and modeling approaches for understanding metabolic pathways and manipulating them through genetic, media, or environmental means. Effective exploration of metabolic pathways necessitates the use of molecular biology and biochemistry methods, as well as engineering techniques for modeling and data analysis. MBE serves as a platform for interdisciplinary research in fields such as biochemistry, molecular biology, applied microbiology, cellular physiology, cellular nutrition in health and disease, and biochemical engineering. The journal publishes various types of papers, including original research papers and review papers. It is indexed and abstracted in databases such as Scopus, Embase, EMBiology, Current Contents - Life Sciences and Clinical Medicine, Science Citation Index, PubMed/Medline, CAS and Biotechnology Citation Index.