Cas12a knockin mice expand the toolbox for in vivo and ex vivo multiplexed genome editing

IF 8.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2025-07-21 DOI:10.1016/j.devcel.2025.05.012

Filippo Birocchi, Marcela V. Maus

引用次数: 0

Abstract

Multiplex genome editing is critical for advancing transformative gene therapies and unraveling complex genetic interactions. In a recent issue of Nature Biomedical Engineering, Tang et al. introduced Cas12a knockin mice, providing a versatile platform for disease modeling and the development of multiplexed therapeutic strategies.

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Cas12a敲入小鼠扩展了体内和体外多重基因组编辑工具箱

多重基因组编辑对于推进变革性基因治疗和揭示复杂的基因相互作用至关重要。在最近一期的《自然生物医学工程》杂志上，Tang等人介绍了Cas12a敲入小鼠，为疾病建模和多种治疗策略的开发提供了一个多功能平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.