Advances in Nature-Inspired Particles for Bioanalytical Applications.

IF 27.4 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials Pub Date : 2025-07-21 DOI:10.1002/adma.202510312

Yongyang Song,Shutao Wang

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引用次数: 0

Abstract

Nature has evolved sophisticated prototypes to achieve functions from efficient separation to selective capture, targeted interaction, and interactive communication. These biological blueprints provide transformative inspiration for engineering advanced particle materials tailored for bioanalytical challenges. This review comprehensively examines recent advances in nature-inspired particles from natural prototypes to preparation methods and various bioanalytical applications. The design principle of nature-inspired particles originates from the unique chemical and topological characteristics of natural prototypes including biomolecules (proteins and nucleic acids), subcellular particles (virus, extracellular vesicles (EVs), bacteria, and platelet), cells (erythrocyte, sperm cell, immune cell, and pollen), creatures (urchin and hedgehog), and minerals (zeolites). Various preparation methods have been developed to replicate the intricate features of these prototypes. These nature-inspired particles have demonstrated effectiveness in bioanalytical applications, such as i) adsorption, separation, and removal of biological molecules, ii) interaction, recognition, and capture of biological particles, iii) biological sensing, and iv) biological imaging. Some existing challenges and potential research opportunities have also been indicated in bioanalytical practice. It is anticipated that more nature-inspired particles would be created with programmable chemistry and topology, exhibiting integrated functions, and benefiting various practical bioanalytical applications with the assistance of artificial intelligence (AI) and big data processing.

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自然启发粒子在生物分析中的应用进展。

大自然已经进化出复杂的原型，以实现从有效分离到选择性捕获、有针对性的互动和互动交流的功能。这些生物蓝图为为生物分析挑战量身定制的工程先进颗粒材料提供了革命性的灵感。本文综述了从天然原型到制备方法和各种生物分析应用的自然启发颗粒的最新进展。自然灵感颗粒的设计原理源于自然原型的独特化学和拓扑特征，包括生物分子（蛋白质和核酸）、亚细胞颗粒（病毒、细胞外囊泡（EVs）、细菌和血小板）、细胞（红细胞、精子细胞、免疫细胞和花粉）、生物（海胆和刺猬）和矿物质（沸石）。人们开发了各种制备方法来复制这些原型的复杂特征。这些受自然启发的颗粒已经在生物分析应用中证明了有效性，例如i)生物分子的吸附、分离和去除，ii)生物颗粒的相互作用、识别和捕获，iii)生物传感和iv)生物成像。指出了生物分析实践中存在的一些挑战和潜在的研究机会。预计在人工智能（AI）和大数据处理的帮助下，将创造出更多具有可编程化学和拓扑结构的自然启发粒子，展示集成功能，并有利于各种实际生物分析应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Materials 工程技术-材料科学：综合

CiteScore

43.00

自引率

4.10%

发文量

2182

审稿时长

2 months

期刊介绍： Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.