Using Comparative Transcriptomics and Histology to Identify Significant Differentially Expressed Genes Associated with Retained Placenta in Humans and Rhesus Macaques (Macaca mulatta).

Journal of the American Association for Laboratory Animal Science : JAALAS Pub Date : 2025-05-01 DOI:10.30802/AALAS-JAALAS-25-007

Sona Jasani, Athmika Vaseeharan, Anamika Singh, Erik Washburn, Melissa Stovall, Hannah Atkins, Danielle Covington

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Abstract

Retained placenta is an important reproductive complication that affects humans and nonhuman primates (NHPs). Accurate prediction of retained placenta in both species is a current challenge because the etiology is unknown, biomarkers are inadequate, and data are heterogeneous. Through a comparative approach, this study identifies 34 significantly differentially expressed genes associated with retained placenta shared between humans and NHPs. Pathway enrichment revealed upregulation in innate and adaptive immunity in addition to pathways related to hemostasis. Retained placentas in NHPs had higher histologic evidence of inflammation as compared with human samples. These cross-species transcriptional results can serve as an initial step to guide NHP refinement as a model system and inform retained placenta biomarker discovery in both humans and NHPs.

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使用比较转录组学和组织学鉴定与人类和恒河猴（Macaca mulatta）保留胎盘相关的显著差异表达基因。

保留胎盘是影响人类和非人灵长类动物（NHPs）的重要生殖并发症。准确预测这两个物种的胎盘残留是目前的一个挑战，因为病因未知，生物标志物不足，数据不均匀。通过比较方法，本研究确定了34个与人类和NHPs共享的保留胎盘相关的显著差异表达基因。途径富集表明，除了与止血相关的途径外，先天免疫和适应性免疫也上调。与人类样本相比，NHPs中保留的胎盘具有更高的炎症组织学证据。这些跨物种转录结果可以作为指导NHP细化模型系统的第一步，并为人类和NHP中保留的胎盘生物标志物的发现提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of the American Association for Laboratory Animal Science : JAALAS

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