Idiopathic recurrent acute pancreatitis: current and future approaches to management.

IF 2.5 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Current Opinion in Gastroenterology Pub Date : 2025-07-14 DOI:10.1097/MOG.0000000000001122

Pranjal Singh, Soumya Jagannath Mahapatra, Pramod Kumar Garg

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引用次数: 0

Abstract

Purpose of review: Idiopathic recurrent acute pancreatitis (IRAP) is a clinically relevant condition with a high likelihood of progression to chronic pancreatitis (CP) in 20-50% of patients. This review outlines the importance of early diagnosis of IRAP and potential upcoming therapies to halt disease progression. It highlights a potential therapeutic window in the natural history of IRAP.

Recent findings: Despite advancements in diagnostic modalities, identifying a definitive aetiology remains challenging in a significant proportion of cases. Current approaches emphasize structured, stepwise evaluation including metabolic, genetic, and structural factors. Emerging therapies aim to target inflammation, trypsin activation, and pancreatic fibrosis.

Summary: While diagnostic tools have improved, therapeutic options remain limited in IRAP. Early identification of modifiable risk factors, use of advanced imaging, and application of evolving treatment strategies may offer an opportunity to prevent the transition from IRAP to CP. Future research must focus on validating disease-modifying treatments and optimizing individualized management strategies.

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特发性复发性急性胰腺炎：当前和未来的管理方法。

综述目的：特发性复发性急性胰腺炎（IRAP）是一种临床相关疾病，20-50%的患者极有可能发展为慢性胰腺炎（CP）。这篇综述概述了早期诊断IRAP的重要性以及即将到来的阻止疾病进展的潜在治疗方法。它突出了IRAP自然史中一个潜在的治疗窗口。最近的发现：尽管在诊断方式上取得了进步，但在很大一部分病例中，确定明确的病因仍然具有挑战性。目前的方法强调结构化的、逐步的评估，包括代谢、遗传和结构因素。新兴疗法的目标是炎症、胰蛋白酶激活和胰腺纤维化。总结：虽然诊断工具有所改进，但IRAP的治疗选择仍然有限。早期识别可改变的危险因素、使用先进的成像技术和应用不断发展的治疗策略可能为防止从IRAP向CP过渡提供机会。未来的研究必须集中在验证疾病改善治疗和优化个性化管理策略上。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Gastroenterology 医学-胃肠肝病学

CiteScore

5.30

自引率

0.00%

发文量

137

审稿时长

6-12 weeks

期刊介绍： Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in Gastroenterology features hand-picked review articles from our team of expert editors. With twelve disciplines published across the year – including gastrointestinal infections, nutrition and inflammatory bowel disease – every issue also contains annotated references detailing the merits of the most important papers.