Development of a Predictive Model for Kummell's Disease.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

World neurosurgery Pub Date : 2025-07-16 DOI:10.1016/j.wneu.2025.124293

Yiliang Song, Houling Zhao, Shisheng Liu, Qi Liu, Yucheng Qi, Gang Wei, Hongliang Song

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引用次数: 0

Abstract

Background: Kümmell's disease (KD) is a recognized complication of osteoporotic thoracolumbar vertebral compression fractures (OVCFs), but the risk factors for progression from OVCFs to KD remain unclear.

Methods: This retrospective study included 104 patients with OVCFs from a tertiary hospital between January 2020 and December 2023. Patients were divided into a case group (56 patients with KD) and a control group (48 patients without KD). Data on 24 variables, including demographics, fracture characteristics, and biochemical markers, were collected and analyzed using SPSS 25.0 software. Statistical methods included independent samples t-test, Mann-Whitney U test, chi-square test, Fisher's exact test, and binary logistic regression.

Results: Univariate analysis identified five significant factors related to KD onset: age, vertebral length, intervertebral foramen width, alkaline phosphatase, and albumin. Binary logistic regression analysis revealed three independent risk factors for KD: vertebral length, alkaline phosphatase, and albumin.

Conclusion: When treating OVCF patients, clinicians should consider comprehensive factors. Patients with high alkaline phosphatase levels, longer fractured vertebrae, and low albumin levels should be closely monitored. Targeted interventions, such as early surgery, enhanced nutrition, and optimized anti-osteoporosis plans, may reduce KD risk and improve patient outcomes.

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Kummell病预测模型的建立。

背景：k mmell病（KD）是骨质疏松性胸腰椎压缩性骨折（OVCFs）的一种公认的并发症，但从OVCFs发展为KD的危险因素尚不清楚。方法：本回顾性研究纳入了2020年1月至2023年12月在某三级医院就诊的104例OVCFs患者。患者分为病例组（56例有KD）和对照组（48例无KD）。收集包括人口统计学、骨折特征和生化指标在内的24个变量的数据，使用SPSS 25.0软件进行分析。统计方法包括独立样本t检验、Mann-Whitney U检验、卡方检验、Fisher精确检验和二元logistic回归。结果：单因素分析确定了与KD发病相关的5个显著因素：年龄、椎体长度、椎间孔宽度、碱性磷酸酶和白蛋白。二元logistic回归分析揭示了KD的三个独立危险因素：椎体长度、碱性磷酸酶和白蛋白。结论：临床医生在治疗OVCF患者时应综合考虑各种因素。对于碱性磷酸酶水平高、骨折时间长、白蛋白水平低的患者应密切监测。有针对性的干预措施，如早期手术、加强营养和优化抗骨质疏松计划，可以降低KD风险并改善患者预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World neurosurgery CLINICAL NEUROLOGY-SURGERY

CiteScore

3.90

自引率

15.00%

发文量

1765

审稿时长

47 days

期刊介绍： World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The journal''s mission is to: -To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care. -To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide. -To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients. Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS