Psychosocial and NF-κB Activity Effects of the Stress Management and Resiliency Training: Relaxation Response Resiliency Program (SMART-3RP) on Patients With MGUS and Smoldering Multiple Myeloma: A Randomized Waitlist Control Trial.

IF 3.5 2区医学 Q2 ONCOLOGY

Psycho‐Oncology Pub Date : 2025-07-01 DOI:10.1002/pon.70216

Lucy Finkelstein-Fox, John W Denninger, Leah E Walsh, Jacob P Laubach, Andrew Jenho Yee, Elizabeth O'Donnell, Eric A Macklin, Xuesong Gu, Alona Muzikansky, Towia A Libermann, Gabriella Nicolosi, Paul G Richardson, Noopur S Raje, Gregory L Fricchione, Giselle K Perez, Lara N Traeger, Emma Chad-Friedman, Elyse R Park

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引用次数: 0

Abstract

Background: Patients with monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM), precursors to multiple myeloma, need supports for the psychological sequelae of medical uncertainty.

Aims: This secondary and exploratory analysis of psychosocial outcomes from a randomized controlled trial evaluated a mind-body intervention, the Stress Management and Resiliency Training: Relaxation Response Resiliency Program (SMART-3RP) for perceived stress, global distress and secondary distress (depression, anxiety, NF-κB DNA-binding activity) and well-being (coping ability, mindfulness, optimism, gratitude) indices for individuals with MGUS and SMM.

Methods: Participants were randomized to immediate treatment (n = 45) or waitlist control (n = 48), providing data at baseline (T1), 3 months (T2), and 6 months (T3).

Results: Compared to waitlist control, the immediate treatment group experienced greater T1-T2 reductions in global distress (M_diff = -1.04, p = 0.04), but not perceived stress (M_diff = -1.67, p = 0.12). Participants receiving immediate treatment also experienced greater reductions in depression (M_diff = -4.22, p < 0.001) and improvements in coping abilities (M_diff = 0.36, p < 0.001) and optimism (M_diff = 1.39, p = 0.02), with no significantly different changes in mindfulness (M_diff = 4.36, p = 0.14), anxiety (M_diff = -1.23, p = 0.26), gratitude (M_diff = 0.59, p = 0.47), or NF-κB activity (M_diff = -0.16, p = 0.23).

Conclusions: The SMART-3RP demonstrated efficacy for global distress and other important outcomes for individuals with MGUS and SMM. Stress reduction did not significantly differ from waitlist control.

Trial registration: ClinicalTrials.gov Registration #: NCT01955395.

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压力管理和弹性训练：放松反应弹性计划（SMART-3RP）对MGUS和阴燃型多发性骨髓瘤患者的心理社会和NF-κB活性影响：一项随机候补对照试验。

背景：患有未确定意义单克隆γ病（MGUS）和阴熏型多发性骨髓瘤（SMM）的患者（多发性骨髓瘤的前体）需要医疗不确定性的心理后遗症的支持。目的：对一项随机对照试验的心理社会结局进行二次和探索性分析，评估身心干预，压力管理和弹性训练：放松反应弹性计划（SMART-3RP）对MGUS和SMM个体的感知压力、整体痛苦和次要痛苦（抑郁、焦虑、NF-κB dna结合活性）和幸福感（应对能力、正念、乐观、感恩）指标的影响。方法：参与者随机分为立即治疗组（n = 45）和候补组（n = 48），分别提供基线（T1）、3个月（T2）和6个月（T3）的数据。结果：与等候名单对照组相比，立即治疗组整体窘迫T1-T2降低幅度更大（Mdiff = -1.04, p = 0.04），但感知压力降低幅度较小（Mdiff = -1.67, p = 0.12）。接受即时治疗的参与者在抑郁方面也有较大的减少（Mdiff = -4.22, p diff = 0.36, p diff = 1.39, p = 0.02），而在正念（Mdiff = 4.36, p = 0.14）、焦虑（Mdiff = -1.23, p = 0.26）、感激（Mdiff = 0.59, p = 0.47）或NF-κB活性（Mdiff = -0.16, p = 0.23）方面没有显著差异。结论：SMART-3RP对MGUS和SMM患者的整体痛苦和其他重要结果显示有效。压力减少与候补名单控制组没有显著差异。试验注册：ClinicalTrials.gov注册号：NCT01955395。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psycho‐Oncology 医学-心理学

CiteScore

6.30

自引率

8.30%

发文量

220

审稿时长

3-8 weeks

期刊介绍： Psycho-Oncology is concerned with the psychological, social, behavioral, and ethical aspects of cancer. This subspeciality addresses the two major psychological dimensions of cancer: the psychological responses of patients to cancer at all stages of the disease, and that of their families and caretakers; and the psychological, behavioral and social factors that may influence the disease process. Psycho-oncology is an area of multi-disciplinary interest and has boundaries with the major specialities in oncology: the clinical disciplines (surgery, medicine, pediatrics, radiotherapy), epidemiology, immunology, endocrinology, biology, pathology, bioethics, palliative care, rehabilitation medicine, clinical trials research and decision making, as well as psychiatry and psychology. This international journal is published twelve times a year and will consider contributions to research of clinical and theoretical interest. Topics covered are wide-ranging and relate to the psychosocial aspects of cancer and AIDS-related tumors, including: epidemiology, quality of life, palliative and supportive care, psychiatry, psychology, sociology, social work, nursing and educational issues. Special reviews are offered from time to time. There is a section reviewing recently published books. A society news section is available for the dissemination of information relating to meetings, conferences and other society-related topics. Summary proceedings of important national and international symposia falling within the aims of the journal are presented.