Impact of prenatal tobacco exposure on brain structure and function in offspring: a systematic review and meta-analysis of MRI findings.

IF 2.6 3区医学 Q2 CLINICAL NEUROLOGY

Neuroradiology Pub Date : 2025-07-19 DOI:10.1007/s00234-025-03696-w

Mohammadamin Parsaei, Pegah Rashidian, Ali Parsaei, Mishka Terplan, Azadeh Tarafdari, Mahdi Masrour, Alireza Beikmarzehei, Parveneh Hassani, Mohsen Motevaselian, Hossein Sanjari Moghaddam

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引用次数: 0

Abstract

Purpose: The increasing global prevalence of maternal smoking during pregnancy raises concerns about lasting effects on fetal neurological development. This review of brain magnetic resonance imaging studies aims to analyze existing literature on the influence of maternal prenatal tobacco exposure on the structure and function of the offspring's brain.

Methods: A systematic search was conducted in PubMed, Web of Science, and Embase for relevant articles published before May 24, 2025. The inclusion criteria consisted of peer-reviewed original articles comparing brain magnetic resonance imaging data of offspring born to mothers with and without prenatal tobacco exposure. A coordinate-based meta-analysis using the activation likelihood estimation was also performed.

Results: Our search resulted in 471 records, with 56 articles undergoing full-text screening. Ultimately, 27 articles comparing the brain magnetic resonance imaging of 15,913 offspring, from fetus to adulthood stages, with and without prenatal tobacco exposure, were included. While the findings of the studies were heterogeneous, multiple regional and global structural (e.g., volume, cortical thickness, and surface area) and functional (task-based) alterations were identified, specifically within the frontal, temporal, and parietal regions. Also, altered white matter tract volume and diffusivity indices were repeatedly reported. Furthermore, our meta-analysis identified reduced neural activity in the right inferior frontal gyrus of tobacco-exposed offspring.

Conclusion: This review highlights a considerable association between maternal smoking during pregnancy and altered offspring brain development. Further studies are essential to discern precise causal effects on the offspring's brain, development, behavior, and function.

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产前烟草暴露对后代大脑结构和功能的影响：MRI结果的系统回顾和荟萃分析。

目的：全球孕妇在怀孕期间吸烟的增加引起了对胎儿神经发育的持久影响的关注。本文综述脑磁共振成像研究，旨在分析母体产前烟草暴露对后代大脑结构和功能影响的现有文献。方法：系统检索2025年5月24日之前发表的PubMed、Web of Science和Embase相关文章。纳入标准包括同行评议的原创文章，比较有和没有产前吸烟母亲所生后代的脑磁共振成像数据。使用激活似然估计进行基于坐标的元分析。结果：我们检索了471条记录，其中56篇文章进行了全文筛选。最终，27篇文章比较了15,913个孩子的脑磁共振成像，从胎儿到成年阶段，有和没有产前吸烟。虽然这些研究的结果是不一致的，但已经确定了多个区域和全球结构（如体积、皮质厚度和表面积）和功能（基于任务的）改变，特别是在额叶、颞叶和顶叶区域。此外，白质束体积和弥漫性指数的改变也被反复报道。此外，我们的荟萃分析发现，吸烟后代的右侧额下回神经活动减少。结论：这篇综述强调了怀孕期间母亲吸烟与改变后代大脑发育之间的相当大的关联。进一步的研究是必要的，以确定对后代的大脑，发育，行为和功能的确切因果影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroradiology 医学-核医学

CiteScore

5.30

自引率

3.60%

发文量

214

审稿时长

4-8 weeks

期刊介绍： Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.