Potential therapeutic target in oncology: Protein palmitoylation (Review).

IF 3.9 3区医学 Q2 ONCOLOGY

Oncology reports Pub Date : 2025-10-01 Epub Date: 2025-07-19 DOI:10.3892/or.2025.8950

Shiping Hao, Yongming Mei, Shaolin Chen, Jing Liu, Yao Zhang, Zhengfeng Zhu, Kangjia Zuo

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引用次数: 0

Abstract

Post‑translational modifications (PTMs) of proteins, by altering the structural conformation of precursor polypeptides, play an indispensable role in augmenting the diversity and stability of the proteome. PTMs exert profound influence on various hallmarks of tumor biology, including cellular proliferation, apoptosis, angiogenesis and metastatic dissemination. Accordingly, advancing our understanding of PTMs holds substantial promise for broadening the therapeutic landscape of oncology. Among these modifications, palmitoylation, a reversible lipid‑based PTM, critically modulates protein stability, membrane localization, protein‑protein interactions and signal transduction cascades. Dysregulation of palmitoylation has been increasingly implicated in tumorigenesis, suggesting its aberrant forms as putative targets for therapeutic intervention. The present review delineates the biochemical mechanisms underlying protein palmitoylation and synthesizes current insights into its multifaceted roles in tumor progression, immune modulation and metabolic regulation, thereby offering novel perspectives for the development of targeted cancer therapies.

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肿瘤的潜在治疗靶点：蛋白棕榈酰化（综述）。

蛋白质的翻译后修饰（ptm）通过改变前体多肽的结构构象，在增加蛋白质组的多样性和稳定性方面发挥着不可或缺的作用。PTMs对肿瘤生物学的各种特征，包括细胞增殖、细胞凋亡、血管生成和转移传播具有深远的影响。因此，推进我们对ptm的理解对于拓宽肿瘤学的治疗前景具有重大的希望。在这些修饰中，棕榈酰化是一种可逆的基于脂质的PTM，对蛋白质稳定性、膜定位、蛋白-蛋白相互作用和信号转导级联起关键调节作用。棕榈酰化的失调越来越多地与肿瘤发生有关，表明其异常形式可能是治疗干预的目标。本文概述了蛋白棕榈酰化的生化机制，并综合了目前对其在肿瘤进展、免疫调节和代谢调节中的多方面作用的见解，从而为靶向癌症治疗的发展提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncology reports 医学-肿瘤学

CiteScore

8.50

自引率

2.40%

发文量

187

审稿时长

3 months

期刊介绍： Oncology Reports is a monthly, peer-reviewed journal devoted to the publication of high quality original studies and reviews concerning a broad and comprehensive view of fundamental and applied research in oncology, focusing on carcinogenesis, metastasis and epidemiology.