The impact of COVID-19 infection on ART outcomes: a multicenter retrospective cohort study.

IF 4.2 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research Pub Date : 2025-07-18 DOI:10.1186/s13048-025-01749-5

Ruiqi Wang, Yaqi Lin, Lixue Chen, Tian Tian, Hongping Wu, Rui Yang, Rong Li, Ping Liu, Jie Qiao

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引用次数: 0

Abstract

Objective: This multicenter retrospective study examines the impact of female COVID-19 infection on assisted reproductive technology (ART) outcomes, including clinical pregnancy rates, miscarriage rates, and live birth rates, and further evaluated potential influencing factors associated with these outcomes.

Methods: Our multicenter retrospective cohort study analyzed 10,140 cycles (2021-2023) from 10 Beijing ART centers, comparing 4,099 cycles from COVID-19-positive women with 6,041 age-matched (1:1.5) COVID-negative controls (pre-pandemic). Outcomes included pregnancy, miscarriage, and live birth rates, analyzed via logistic regression.

Results: In our study, maternal COVID-19 infection showed no significant association with ART outcomes, including clinical pregnancy, miscarriage and live birth. However, subtle differences were still observed. Among women with prior COVID-19 infection, compared to those with transfers ≥ 90 days post-infection (16.1%), miscarriage rates were significantly higher in the < 30 days (20.5%, p = 0.055) and 30-60 days (20.4%, p = 0.032) groups, whereas no increase was observed in the 60-90 days group (15.3%, p = 0.912). Additionally, advanced maternal age and elevated FSH levels (> 10 mIU/mL) were associated with diminished clinical pregnancy and live birth rates. What's more, maternal COVID-19 symptoms and medication use did not significantly affect ART treatment outcomes.

Conclusions: Our results suggest that while maternal COVID-19 infection does not clearly affect overall ART outcomes, embryo transfer within 60 days may increase miscarriage risk. This provides useful guidance for timing treatment during COVID-19 and future public health emergencies.

In brief: Our study found that while a history of the female partner's COVID-19 infection does not significantly impact ART outcomes, miscarriage rates are higher when embryo transfer occurs within 60 days post-infection. We recommend waiting at least 60 days after infection to minimize miscarriage risk.

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COVID-19感染对ART结果的影响：一项多中心回顾性队列研究

目的：本多中心回顾性研究探讨女性COVID-19感染对辅助生殖技术（ART）结局的影响，包括临床妊娠率、流产率和活产率，并进一步评估与这些结局相关的潜在影响因素。方法：我们的多中心回顾性队列研究分析了来自北京10个ART中心的10,140个周期（2021-2023），将covid -19阳性女性的4,099个周期与6,041个年龄匹配（1:1.5）的covid -19阴性对照（大流行前）进行比较。结果包括妊娠、流产和活产率，通过逻辑回归进行分析。结果：在我们的研究中，孕产妇COVID-19感染与ART结局（包括临床妊娠、流产和活产）没有显著相关性。然而，仍然观察到细微的差异。在既往感染COVID-19的妇女中，与感染后≥90天转移的妇女（16.1%）相比，10 mIU/mL的流产率明显更高，与临床妊娠率和活产率降低有关。此外，母亲的COVID-19症状和药物使用并未显着影响ART治疗结果。结论：我们的研究结果表明，虽然母体感染COVID-19对ART的总体结果没有明显影响，但60天内的胚胎移植可能会增加流产风险。这为COVID-19和未来突发公共卫生事件期间的治疗时机提供了有用的指导。简而言之：我们的研究发现，虽然女性伴侣的COVID-19感染史对抗逆转录病毒治疗结果没有显著影响，但在感染后60天内进行胚胎移植时，流产率更高。我们建议在感染后至少等待60天，以尽量减少流产的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Ovarian Research REPRODUCTIVE BIOLOGY-

CiteScore

6.20

自引率

2.50%

发文量

125

审稿时长

>12 weeks

期刊介绍： Journal of Ovarian Research is an open access, peer reviewed, online journal that aims to provide a forum for high-quality basic and clinical research on ovarian function, abnormalities, and cancer. The journal focuses on research that provides new insights into ovarian functions as well as prevention and treatment of diseases afflicting the organ. Topical areas include, but are not restricted to: Ovary development, hormone secretion and regulation Follicle growth and ovulation Infertility and Polycystic ovarian syndrome Regulation of pituitary and other biological functions by ovarian hormones Ovarian cancer, its prevention, diagnosis and treatment Drug development and screening Role of stem cells in ovary development and function.