Results of Patch Testing With a Brazilian Propolis Dilution Series.

IF 4.6 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2025-07-18 DOI:10.1111/cod.70002

Emma M van Oers, Norbertus A Ipenburg, Anton C de Groot, Thomas Rustemeyer

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引用次数: 0

Abstract

Background: Patch testing with Brazilian propolis 10% pet. has yielded very high rates of positive reactions (> 20%). For most, no clinical relevance could be found. False-positive reactions from irritancy of the test material were suggested as a possible explanation.

Objectives: To assess whether positive patch test reactions to Brazilian propolis 10% pet. are allergic, irritant, or may be both.

Materials and methods: In a prospective study, consecutive patients suspected of contact dermatitis were patch tested with Brazilian propolis in a dilution series of 10%, 3.3% and 1% in petrolatum.

Results: Of 200 consecutive patients, 56 (28%) had one or more positive Brazilian propolis patch tests. Eighteen propolis-allergic individuals (32.1%) reacted only to the 10% concentration, 21 patients (37.5%) reacted to all 3 concentrations, 13 (23.2%) to 2 concentrations, and 4 (7.1%) to a lower concentration only. There was a strong association with fragrances, especially with the fragrance mixes 1 and 2.

Conclusions: Our data seem to indicate that the positive patch test reactions to Brazilian propolis 10% pet., or at least a large part thereof, are allergic in nature. Previous fragrance sensitisation may play an important role in the large number of positive patch tests to Brazilian propolis.

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用巴西蜂胶稀释系列进行斑贴试验的结果。

背景：用巴西蜂胶10% pet进行斑贴试验。产生了非常高的积极反应率（约20%）。对于大多数，没有发现临床相关性。测试材料的刺激性引起的假阳性反应被认为是一个可能的解释。目的：评价10%巴西蜂胶pet贴片试验是否有阳性反应。过敏，刺激，或两者兼而有之。材料和方法：在一项前瞻性研究中，连续对疑似接触性皮炎患者进行巴西蜂胶贴片试验，其稀释度分别为10%、3.3%和1%凡士林。结果：在连续200例患者中，56例（28%）有一次或多次巴西蜂胶贴片试验阳性。蜂胶过敏18例（32.1%）仅对10%浓度有反应，21例（37.5%）对3种浓度均有反应，13例（23.2%）对2种浓度有反应，4例（7.1%）只对较低浓度有反应。它与香味有很强的联系，尤其是与香味混合物1和2。结论：我们的数据似乎表明，巴西蜂胶10%的pet贴片试验阳性反应。或至少其中很大一部分，本质上是过敏的。先前的香味致敏可能在巴西蜂胶的大量阳性斑贴试验中起重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".