The role of γδ T cells and CAR-γδ T cell therapy in autoimmune diseases

IF 8.3 1区 医学 Q1 IMMUNOLOGY
Tengyue Wang , Hongli Wang , Rui Lv , Chengping Wen , Mingzhu Wang , Lin Huang
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引用次数: 0

Abstract

Autoimmune diseases represent a major global health challenge, imposing substantial economic, social, and personal burdens on human society. γδ T lymphocytes are a unique T cell subset that bridges innate and adaptive immunity, demonstrating remarkable characteristics in immune regulation and inflammatory modulation. In this context, Chimeric Antigen Receptor (CAR)-γδ T cell therapy emerges as a promising immunotherapeutic strategy with transformative potential in addressing autoimmune disorders. This review comprehensively explores the multifaceted roles of γδ T lymphocytes in autoimmune pathogenesis, highlighting their distinctive functions and properties. It discusses the potential and advantages of applying γδ T cells to CAR-T cell therapy, elucidating the prospects of treating autoimmune diseases through CAR-γδ T cell therapy in the future.

Abstract Image

γδ T细胞和CAR-γδ T细胞治疗在自身免疫性疾病中的作用
自身免疫性疾病是一项重大的全球健康挑战,给人类社会带来了巨大的经济、社会和个人负担。γδ T淋巴细胞是一种独特的T细胞亚群,在先天免疫和适应性免疫之间架起桥梁,在免疫调节和炎症调节中表现出显著的特征。在这种背景下,嵌合抗原受体(CAR)-γδ T细胞治疗成为一种有前途的免疫治疗策略,在解决自身免疫性疾病方面具有变革性潜力。本文综述了γδ T淋巴细胞在自身免疫发病机制中的多方面作用,重点介绍了其独特的功能和特性。讨论了将γδ T细胞应用于CAR-T细胞治疗的潜力和优势,并展望了未来利用CAR-γδ T细胞治疗自身免疫性疾病的前景。
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来源期刊
Autoimmunity reviews
Autoimmunity reviews 医学-免疫学
CiteScore
24.70
自引率
4.40%
发文量
164
审稿时长
21 days
期刊介绍: Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.
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