Association between life's crucial 9 and major eye diseases among US adults aged 40 years or older.

IF 3.5 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

BMC Public Health Pub Date : 2025-07-19 DOI:10.1186/s12889-025-23704-1

Yang Meng, Zongbiao Tan, Yuan Liu, Yuan Ma, Ziye Chen, Lan Jiang, Tao Li

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引用次数: 0

Abstract

Background: Vision impairment due to eye diseases represents a significant global public health concern. There is an increasing acknowledgment of the relationship between cardiovascular health (CVH) and eye diseases. However, Life's Crucial 9 (LC9), the latest scoring framework for CVH, has yet to be investigated in relation to major eye diseases.

Methods: This cross-sectional study included 3830 adults aged 40 years or older from the US National Health and Nutrition Examination Survey 2005-2008. We analyzed the relationship between LC9 scores and major eye diseases, including retinopathy, age-related macular degeneration, cataract, and glaucoma using weighted multivariable logistic regression, restricted cubic spline analysis, and subgroup analyses.

Results: After adjusting for covariates, the poor CVH group (LC9 < 50) exhibited significant higher risks of glaucoma (odds ratio [OR] = 2.37, 95% confidence interval [CI]: 1.11-5.08), retinopathy (OR = 2.92, 95% CI: 1.84-4.63), and any objectively confirmed ocular disease (OR = 2.25, 95% CI: 1.45-3.49) compared to the ideal CVH group (LC9 ≥ 80). Restricted cubic spline analysis demonstrated a significant inverse linear association between LC9 scores and the risk of these diseases. Subgroup analyses indicated significant interactions between LC9 score and sex concerning retinopathy and any objectively confirmed ocular disease.

Conclusions: Suboptimal CVH correlated with increased odds of several major eye diseases in adults aged 40 years or older, highlighting the potential value of CVH optimization for reducing visual impairment burden in this population. Further investigation on the potential causality is warranted.

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在美国40岁及以上的成年人中，生命的关键因素与主要眼病之间的联系。

背景：眼病引起的视力损害是一个重要的全球公共卫生问题。越来越多的人认识到心血管健康（CVH）和眼病之间的关系。然而，生命的关键9 (LC9)， CVH的最新评分框架，尚未调查与主要眼病的关系。方法：这项横断面研究包括3830名40岁以上的成年人，他们来自2005-2008年美国国家健康与营养调查。我们使用加权多变量logistic回归、限制性三次样条分析和亚组分析分析了LC9评分与主要眼病（包括视网膜病变、年龄相关性黄斑变性、白内障和青光眼）之间的关系。结论：在40岁或以上的成年人中，次优CVH与几种主要眼病的发病率增加相关，突出了CVH优化对减轻该人群视力损害负担的潜在价值。有必要进一步调查潜在的因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

4.40%

发文量

2108

审稿时长

1 months

期刊介绍： BMC Public Health is an open access, peer-reviewed journal that considers articles on the epidemiology of disease and the understanding of all aspects of public health. The journal has a special focus on the social determinants of health, the environmental, behavioral, and occupational correlates of health and disease, and the impact of health policies, practices and interventions on the community.