A rare case of type IV hypersensitivity: Prilocaine allergy.

IF 2.1 4区 医学 Q3 ALLERGY
Allergologia et immunopathologia Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI:10.15586/aei.v53i4.1382
Özge Argın, Mustafa Asım Demirkol, Yunus Bozkurt, Nihal Yıldırım, Zeynep Yegin Katran, İsmet Bulut
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引用次数: 0

Abstract

Allergic reactions caused by local anesthetics are quite rare and these reactions often manifest as Type I (immediate-type) hypersensitivity; however, Type IV (delayed-type) hypersensitivity reactions also hold clinical significance. Type IV reactions are generally T-lymphocyte mediated and symptoms appear hours or days after antigen exposure. In this case report, a rare Type IV hypersensitivity reaction to prilocaine, an amide-type local anesthetic, is described. The patient presented to our center due to the delayed-onset skin lesions that developed after previous surgical procedures and was evaluated through comprehensive allergy testing. A positive delayed-type reaction to prilocaine was observed in the intradermal and patch tests; however, no reaction was detected in the provocation test performed with mepivacaine. This highlights the importance of careful selection of local anesthetics and consideration of Type IV hypersensitivity. Sharing such cases contributes to increased clinical awareness.

罕见的IV型过敏症:丙洛卡因过敏。
局麻药引起的过敏反应是相当罕见的,这些反应通常表现为I型(立即型)超敏反应;然而,IV型(延迟型)超敏反应也具有临床意义。IV型反应通常由t淋巴细胞介导,症状在接触抗原数小时或数天后出现。在这个病例报告中,描述了一种罕见的对苯胺型局部麻醉剂丙洛卡因的IV型超敏反应。该患者因既往手术后出现的延迟性皮肤病变而来到我们中心,并通过全面的过敏测试进行评估。皮内和贴片试验中观察到对丙罗卡因的延迟型阳性反应;然而,在用甲哌卡因进行的激发试验中未检测到反应。这突出了仔细选择局部麻醉剂和考虑IV型超敏反应的重要性。分享这些病例有助于提高临床认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.
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