The mechanism underlying the association between ABO blood groups and allergic diseases: an evidence-based systematic review.

IF 2.1 4区 医学 Q3 ALLERGY
Allergologia et immunopathologia Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI:10.15586/aei.v53i4.1287
Abdulrahman Salem Bahashwan
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引用次数: 0

Abstract

This systematic review investigates the connections between ABO blood groups and allergic diseases by analyzing the existing literature to uncover underlying immunological mechanisms. Our search of PubMed, Google Scholar, and the Cochrane Database identified 35 relevant studies, with 10 articles meeting our inclusion criteria. Results suggest that blood group antigens significantly influence immune responses through interactions with immunoglobulin E (IgE) and variations in cytokine profiles. This review highlights the impact of blood group antigens on IgE and cytokine profiles, the relationship between blood group types and allergic disease susceptibility, and the role of gut microbiota in allergy development. The evidence indicates that immunological mechanisms involving IgE antibodies and cytokine signaling play a crucial role in mediating the relationship between blood groups and allergies. Our findings underscore the importance of further research into the immunological pathways linking blood groups to allergic diseases, potentially informing the development of personalized treatments and preventative measures.

ABO血型与过敏性疾病之间关联的潜在机制:一项基于证据的系统综述
本系统综述通过分析现有文献,探讨ABO血型与变应性疾病之间的联系,揭示潜在的免疫机制。我们检索了PubMed、b谷歌Scholar和Cochrane数据库,确定了35项相关研究,其中10篇文章符合我们的纳入标准。结果表明,血型抗原通过与免疫球蛋白E (IgE)的相互作用和细胞因子谱的变化显著影响免疫反应。本文综述了血型抗原对IgE和细胞因子谱的影响,血型与过敏性疾病易感性的关系,以及肠道微生物群在过敏发展中的作用。有证据表明,包括IgE抗体和细胞因子信号在内的免疫机制在介导血型和过敏之间的关系中起着至关重要的作用。我们的发现强调了进一步研究将血型与过敏性疾病联系起来的免疫途径的重要性,可能为个性化治疗和预防措施的发展提供信息。
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.
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