Mining the gut microbiota for defluorination activity.

IF 11 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2025-07-18 DOI:10.1016/j.tibs.2025.07.003

Camille V Goemans

引用次数: 0

Abstract

The gut microbiota harbors a vast array of enzymes, many with unknown functions. In a recent study, Probst et al. mined this ecosystem to identify potential defluorinating enzymes. Combining molecular dynamics, alanine scanning, and machine learning, they uncovered molecular features critical for defluorination enzymatic activity in human gut microbes.

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挖掘肠道微生物群的除氟活性。

肠道菌群中含有大量的酶，其中许多酶的功能未知。在最近的一项研究中，Probst等人挖掘了这个生态系统，以确定潜在的除氟酶。结合分子动力学、丙氨酸扫描和机器学习，他们发现了人类肠道微生物中除氟酶活性的关键分子特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.