Etiologies and clinical characteristics of primary amenorrhea: A study from a quaternary care hospital in southern Thailand

IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
Krantarat Peeyananjarassri, Satit Klangsin, Patchayapan Bhumsiriwilai, Saranya Wattanakumtornkul, Rassamee Chotipanvithayakul
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引用次数: 0

Abstract

Aim

This study aimed to investigate the causes and clinical characteristics of patients presenting with primary amenorrhea.

Methods

A retrospective review was conducted on patients diagnosed with primary amenorrhea at a quaternary care center in southern Thailand between January 2002 and September 2024. Patients with missing data or ambiguous genitalia were excluded. Primary amenorrhea was categorized into three main etiologies: hypergonadotropic hypogonadism (characterized by low serum estradiol and elevated follicle-stimulating hormone [FSH] levels, indicative of ovarian or gonadal disorders), hypogonadotropic hypogonadism (low serum estradiol with low or normal serum FSH levels, associated with hypothalamic–pituitary dysfunction), and eugonadotropic eugonadism (disorders of the uterus or genital outflow tract). Other conditions included anovulation, hyperprolactinemia, and thyroid disorders.

Results

Of the 320 patients included, 150 (46.9%) were classified as having eugonadotropic eugonadism. Among these, Müllerian agenesis was the most common cause (33.8%), followed by gonadal dysgenesis (28.8%). Patients with genital outflow tract obstruction were diagnosed at a significantly younger median age compared to those with Müllerian agenesis (14 years [interquartile range; IQR 13, 16] vs. 20 years [IQR 18, 24]; p < 0.001). Serum FSH levels differed significantly across the three main categories, with higher levels observed in hypergonadotropic hypogonadism (81.1 IU/L [IQR 65.2, 95.0]) compared to hypogonadotropic hypogonadism (0.8 IU/L [IQR 0.3, 3.4]) and eugonadotropic eugonadism (5.2 IU/L [IQR 3.5, 6.3], p < 0.001). Among patients with hypergonadotropic hypogonadism and hypogonadotropic hypogonadism who underwent ultrasonography (USG) (n = 100), the uterus was not visualized in 44 cases.

Conclusion

Müllerian agenesis emerged as the most frequent cause of primary amenorrhea, although it tended to be diagnosed later than genital outflow tract obstruction. Caution is warranted when assessing the presence of the uterus by USG, particularly in patients with hypergonadotropic hypogonadism or hypogonadotropic hypogonadism.

原发性闭经的病因和临床特征:来自泰国南部一家四级护理医院的研究
目的探讨原发性闭经患者的病因及临床特点。方法回顾性分析2002年1月至2024年9月在泰国南部一家第四保健中心诊断为原发性闭经的患者。数据缺失或生殖器模糊的患者被排除在外。原发性闭经主要分为三种病因:高促性腺功能减退症(以低血清雌二醇和高卵泡刺激素水平为特征,表明卵巢或性腺功能紊乱)、低促性腺功能减退症(低血清雌二醇,低或正常血清卵泡刺激素水平,与下丘脑-垂体功能障碍有关)和促性腺功能减退症(子宫或生殖器流出道紊乱)。其他情况包括无排卵、高催乳素血症和甲状腺疾病。结果320例患者中,150例(46.9%)为促性腺激素功能亢进。其中最常见的原因是勒氏发育不全(33.8%),其次是性腺发育不良(28.8%)。与勒氏杆菌发育不全患者相比,生殖器流出道梗阻患者的诊断中位年龄明显更年轻(14岁[四分位数范围;[IQR 18, 24];p < 0.001)。血清促性腺激素水平在三个主要类别中存在显著差异,与促性腺功能减退症(0.8 IU/L [IQR 0.3, 3.4])和促性腺功能减退症(5.2 IU/L [IQR 3.5, 6.3], p < 0.001)相比,促性腺功能减退症(81.1 IU/L [IQR 65.2, 95.0])的血清促性腺激素水平较高。在100例高促性腺功能减退和低促性腺功能减退患者中,44例未见子宫。结论勒氏杆菌发育不全是原发性闭经最常见的原因,但其诊断往往晚于生殖器流出道梗阻。在使用超声心动图评估子宫的存在时需要谨慎,特别是在患有高促性腺功能减退症或促性腺功能减退症的患者中。
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来源期刊
CiteScore
3.10
自引率
0.00%
发文量
376
审稿时长
3-6 weeks
期刊介绍: The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.
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