Pregnancy-specific reference intervals for complete blood count parameters in a Japanese cohort

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-07-21 DOI:10.1111/jog.70011

Kanatsu Kawakami, Shimokawa Risa, Fumitaka Saito, Akihito Sagara, Saori Yoshimura, Yutaka Iwagoi, Munekage Yamaguchi, Shoichi Kawakami, Eiji Kondoh

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引用次数: 0

Abstract

Aim

To establish gestational age-specific reference intervals for complete blood count (CBC) parameters in a Japanese population and examine the influence of maternal body mass index (BMI) and age.

Methods

A retrospective cohort study was conducted at a single institution, analyzing eight CBC parameters in 33 355 singleton pregnancies. Reference intervals (2.5th–97.5th percentiles) for white blood cell count (WBC), red blood cell count (RBC), hemoglobin (Hb), hematocrit (Ht), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and platelet count (PLT) were determined across early (<20 weeks), mid (20–29 weeks), and late (≥30 weeks) pregnancy. One-way analysis of variance with Tukey's intervals assessed the impact of BMI and age.

Results

Up to 69 758 values per parameter were analyzed. WBC, MCV, and MCH increased in mid-pregnancy and then declined, while RBC and Ht reached their lowest levels in mid-pregnancy before partial recovery. Hb, MCHC, and PLT steadily decreased. Higher BMI was associated with higher WBC, RBC, Hb, Ht, and PLT at all gestational periods (p < 0.001). WBC declined, whereas MCV and MCH increased with maternal age, with more marked differences in late pregnancy. Hb decline was more evident in teenagers and women in their early 20s. Longitudinal comparisons showed lower WBC and higher PLT in the latest pregnancy compared to the preceding one (p < 0.001).

Conclusions

This study provides pregnancy-specific CBC reference intervals and highlights the need to consider BMI- and age-related factors in prenatal hematological assessment.

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日本队列全血细胞计数参数的妊娠特异性参考区间

目的建立日本人群全血细胞计数（CBC）参数的妊娠年龄特异性参考区间，并研究母亲体重指数（BMI）和年龄的影响。方法采用回顾性队列研究，对33 355例单胎妊娠的8项CBC参数进行分析。在妊娠早期（20周）、中期（20 - 29周）和晚期（≥30周）测定白细胞计数（WBC）、红细胞计数（RBC）、血红蛋白（Hb）、红细胞压积（Ht）、平均红细胞体积（MCV）、平均红细胞血红蛋白（MCH）、平均红细胞血红蛋白浓度（MCHC）和血小板计数（PLT）的参考区间（2.5 - 97.5%）。用Tukey's区间进行单向方差分析，评估BMI和年龄的影响。结果每个参数最多可分析69 758个值。WBC、MCV和MCH在妊娠中期先升高后下降，而RBC和Ht在妊娠中期达到最低水平，然后部分恢复。Hb、MCHC、PLT稳步下降。在所有妊娠期，较高的BMI与较高的WBC、RBC、Hb、Ht和PLT相关（p < 0.001）。WBC下降，而MCV和MCH随母亲年龄的增加而增加，在妊娠后期差异更明显。血红蛋白下降在青少年和20岁出头的女性中更为明显。纵向比较显示，与前一次妊娠相比，最近一次妊娠的WBC较低，PLT较高（p < 0.001）。本研究提供了妊娠特异性CBC参考区间，并强调了在产前血液学评估中考虑BMI和年龄相关因素的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.