Assessing the Impact of Neuromuscular Taping on Thrombocyte Indices in Diabetic Neuropathy Patients With Peripheral Artery Disease: A Cross-Sectional Study

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports Pub Date : 2025-07-20 DOI:10.1002/hsr2.70919

Nurul Aktifah, Firman Faradisi, Muhammad Ghilang Maulud Setyawan, Nuniek Nizmah Fajriyah, Eko Mugiyanto, Umi Budi Rahayu

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Abstract

Background and Aims

Peripheral artery disease (PAD) is a common complication among diabetic neuropathy patients, often associated with abnormalities in thrombocyte indices. This study aimed to assess the impact of neuromuscular taping (NMT) on thrombocyte indices in diabetic neuropathy patients with PAD.

Methods

A total of 23 patients diagnosed with DN using the Toronto Clinical Neuropathy Scoring System (TCNSS) and Diabetic Neuropathy Examination (DNE) were enrolled in the study. Participants underwent NMT decompression intervention sessions over a period of 24 days. Further, the genomic analysis utilized public databases derived from diabetes studies that investigated the development of diabetic neuropathy.

Results

The result revealed, pre- and post-intervention measurements demonstrated significant improvements in thrombocyte indices, particularly in platelet distribution width, platelet count, and mean platelet volume, among patients undergoing NMT (p < 0.05). Additionally, there was a notable decrease in TCNSS and DNE scores post-intervention, indicating an improvement in DN symptoms. Moreover, genomic analysis identified 9 genes, including SLC30A1, TRBJ2-7, OLFM1, TCF7L2, MCF2L, CEP295NL, CEACAM22P, TSHZ2, and PDZD4, involved in DN development.

Conclusion

These findings suggest that NMT holds promise as a therapeutic intervention for improving thrombocyte indices and managing DN symptoms in patients with PAD. Further research is warranted to elucidate the underlying mechanisms and long-term effects of NMT in this population.

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评估神经肌肉贴敷对糖尿病神经病变合并外周动脉疾病患者血栓细胞指数的影响：一项横断面研究

背景和目的外周动脉病变（PAD）是糖尿病神经病变患者的常见并发症，通常与血小板指数异常有关。本研究旨在评估神经肌肉贴敷（NMT）对糖尿病神经病变伴PAD患者血栓细胞指数的影响。方法采用多伦多临床神经病变评分系统（TCNSS）和糖尿病神经病变检查（DNE）诊断为DN的患者共23例。参与者接受为期24天的NMT减压干预。此外，基因组分析利用了来自糖尿病研究的公共数据库，这些研究调查了糖尿病神经病变的发展。结果显示，NMT患者在干预前和干预后的血小板指数，特别是血小板分布宽度、血小板计数和平均血小板体积均有显著改善（p < 0.05）。此外，干预后TCNSS和DNE评分显著下降，表明DN症状有所改善。此外，基因组分析鉴定出SLC30A1、TRBJ2-7、OLFM1、TCF7L2、MCF2L、CEP295NL、CEACAM22P、TSHZ2和PDZD4等9个基因参与DN的发生。结论这些发现表明，NMT有望作为改善PAD患者血小板指数和控制DN症状的治疗干预措施。需要进一步的研究来阐明NMT在这一人群中的潜在机制和长期影响。

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