First and Second-Trimester Screening, for Down's Syndrome: An Umbrella Review on Meta-Analyses

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports Pub Date : 2025-07-21 DOI:10.1002/hsr2.70910

Zahra Goudarzi, Mojtaba Jafari, Zahra Shirvani, Mahmood Salesi, Khosro Keshavarz, Bahya Namvar Jahromi

{"title":"First and Second-Trimester Screening, for Down's Syndrome: An Umbrella Review on Meta-Analyses","authors":"Zahra Goudarzi, Mojtaba Jafari, Zahra Shirvani, Mahmood Salesi, Khosro Keshavarz, Bahya Namvar Jahromi","doi":"10.1002/hsr2.70910","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background and Aim</h3>\n \n <p>Despite the variety of screening tests, the number of babies born with Down's syndrome (DS) has not significantly decreased. The aim of this study was systematically review previously published meta-analysis studies to identify the most efficient screening tests for DS during only the first trimester (FT) and only in the second trimester (ST) of pregnancy.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The data sources, including Scopus, Cochrane Library, and PubMed, were reviewed. The effectiveness of tests was investigated and compared by extracting their sensitivity and specificity values from meta-analyses. The heterogeneity of data was investigated by <i>χ</i><sup>2</sup> and <i>I</i><sup>2</sup> tests. In addition, publication bias was assessed through Egger's and Begg's tests.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>This study investigated 14 eligible and high-quality meta-analyses. Meta-analysis of 13 studies revealed FT and ST as the best stage for conducting serum tests, with a sensitivity of 0.824 (CI: 0.790–0.857) and specificity of 0.956 (CI: 0.947–0.965). Likewise, FT and ST were found as the best stage for conducting ultrasound tests, with a sensitivity of 0.882 (CI: 0.850–0.914) and a specificity of 0.95 (CI: 0.944–0.956). In addition, ST was determined as the best stage for carrying out ultrasound (US) and serum screening (SS) tests, with a sensitivity of 0.93 and a specificity of 0.93, indicating the highest sensitivity and specificity of US + SS tests in the ST than FT and FT & ST stages.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The first and second trimesters (FT and ST) is the best stage for carrying out ultrasound and serum screening tests. ST was found to be the best stage for conducting US + SS in DS screening tests. US + SS tests achieved the best results for DS screening during the FT and ST of pregnancy.</p>\n </section>\n </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 7","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70910","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Health Science Reports","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hsr2.70910","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background and Aim

Despite the variety of screening tests, the number of babies born with Down's syndrome (DS) has not significantly decreased. The aim of this study was systematically review previously published meta-analysis studies to identify the most efficient screening tests for DS during only the first trimester (FT) and only in the second trimester (ST) of pregnancy.

Methods

The data sources, including Scopus, Cochrane Library, and PubMed, were reviewed. The effectiveness of tests was investigated and compared by extracting their sensitivity and specificity values from meta-analyses. The heterogeneity of data was investigated by χ² and I² tests. In addition, publication bias was assessed through Egger's and Begg's tests.

Results

This study investigated 14 eligible and high-quality meta-analyses. Meta-analysis of 13 studies revealed FT and ST as the best stage for conducting serum tests, with a sensitivity of 0.824 (CI: 0.790–0.857) and specificity of 0.956 (CI: 0.947–0.965). Likewise, FT and ST were found as the best stage for conducting ultrasound tests, with a sensitivity of 0.882 (CI: 0.850–0.914) and a specificity of 0.95 (CI: 0.944–0.956). In addition, ST was determined as the best stage for carrying out ultrasound (US) and serum screening (SS) tests, with a sensitivity of 0.93 and a specificity of 0.93, indicating the highest sensitivity and specificity of US + SS tests in the ST than FT and FT & ST stages.

Conclusion

The first and second trimesters (FT and ST) is the best stage for carrying out ultrasound and serum screening tests. ST was found to be the best stage for conducting US + SS in DS screening tests. US + SS tests achieved the best results for DS screening during the FT and ST of pregnancy.

Abstract Image

查看原文本刊更多论文

唐氏综合症的妊娠早期和中期筛查：荟萃分析综述

背景和目的尽管有各种各样的筛查试验，出生时患有唐氏综合症（DS）的婴儿数量并没有显著减少。本研究的目的是系统地回顾以前发表的荟萃分析研究，以确定仅在妊娠前三个月（FT）和仅在妊娠中期（ST）最有效的DS筛查试验。方法对Scopus、Cochrane Library、PubMed等文献资料进行回顾性分析。通过从荟萃分析中提取其敏感性和特异性值来调查和比较测试的有效性。采用χ2和I2检验检验数据的异质性。此外，通过Egger's和Begg's检验评估发表偏倚。结果本研究调查了14项合格的高质量荟萃分析。13项研究的meta分析显示，FT和ST是进行血清检测的最佳阶段，敏感性为0.824 (CI: 0.790 ~ 0.857)，特异性为0.956 （CI: 0.947 ~ 0.965）。同样，FT和ST是超声检查的最佳阶段，灵敏度为0.882 (CI: 0.850-0.914)，特异性为0.95 （CI: 0.944-0.956）。此外，ST期是开展超声（US）和血清筛查（SS）试验的最佳阶段，敏感性为0.93，特异性为0.93，表明US + SS试验在ST期的敏感性和特异性均高于FT和FT &；圣阶段。结论妊娠早期和中期（FT和ST）是开展超声和血清筛查试验的最佳阶段。在DS筛选试验中发现ST是进行US + SS的最佳阶段。US + SS检测在妊娠前期和ST期的DS筛查中效果最好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊