Bivalent prefusion F vaccination in pregnancy and respiratory syncytial virus hospitalisation in infants in the UK: results of a multicentre, test-negative, case-control study
Thomas C Williams PhD, Robin Marlow PhD, Prof Steve Cunningham PhD, Simon B Drysdale PhD, Helen E Groves MB BCh BAO PhD, Samantha Hunt BSc, Dalia Iskander PhD, Xinxue Liu PhD, Mark D Lyttle MBChB, Chengetai D Mpamhanga MSc, Shaun O'Hagan MB BCh BAO, Thomas Waterfield PhD, Damian Roland PhD, PERUKI & BronchStart Collaboration, Catriona M Middleton, Maggie Connon, Jill M Paxton, Nicola Thomson, James Thomas Baker, Susie R Hardwick, Karena Jan Fraser, Kathryn Frances Kimber, Asa JE French, Meriel FJ Tolhurst-Cleaver, Sarah Siner, Stephen Fletcher, Karen Geoghegan, Laura Ann Tremarco, Kelly Curran, Cynthia Dzokoto Diaba, Chidinma Joanne Iheanetu-Oguejiofor, Lobsong Dolma, Stephen Waithaka Ruo, Richard Benjamin Stuart Berg, Sara Mohammed Osman Farah, Elena Kehtarnavaz, Abigail Louise Whitehouse, Grace E Wild, Sobia Siraj, Ioannis Kyrgios, Amutha Anpananthar, Lee James Tubman, Sunil S Bhopal, Jessica Reynolds, Gabrielle Larkin, Elizabeth Ledger, Ruth E Bonsor, Dodd Hopgood, Robert Eggen, Katy Lillie, Mat Stuart, Alison O'Kelly, Chiara De Leonardis, Stephen P Brearey, Caroline A Burchett, Sarah E de-Beger, Claire Bell, Babu G Benjamin, Sarah E Farmer, Mudiyur Gopi, Natalie Keenan, Jen G Browning, Caroline Blackstock, Rachel O'Brien, Sylvester S Gomes, Gracita M Woods, Dilini Vasanthakumar, Kayleigh Kanhai, Heather J Jarman, Zee R Karame, Steve J Foster, Susanne Cathcart, Louise E Edwards, James R Poole-Cowley, Samantha E Hunt, Joanne L Tomlinson, Jo William Tillett, Simon R Dowson, Surendra T Singham, Perpetual S Palmer, Eilidh E Grant, Pauline Miller, Kelum K Perera, Jasmine L Stares, Manuela E Brazil, Sharryn Gardner, Kerri Bowness, Moira Morrison, Nicholas Richens, Heather Deall, Jemma Parratt, Stephanie - Grigsby, Nina Vanner, Francesca Diaz, Graham Johnson, Jonathan Riley, Alison Fletcher, Lianne Hufton, Alison Rockey, Alison Matthews, Claire Fearn, Elisha Cousins, Katie Louise Bub, Cynthia Dzokoto Diaba, Chidinma Joanne Iheanetu-Oguejiofor, Lobsong Dolma, Stephen Waithaka Ruo, Elena Kehtarnavaz, George R Hamson, Hannah Randall, Jessica J Evans, Virginia J Griffiths, Sarah L Diment, Sebastian J Gray, Nikki Leanne Furness, Stuart Gormley, Rebecca Scott, Victoria Bamber, Kathryn Jones, Megan Wilcock, Louise A Fairlie, Rophy Ganancial Nunes, Niall G Mullen, Clare O'Leary, Kerri Bowness, Richard George Burridge, Katrina S Hall, Leanne M Taylor, Lily J Kirkpatrick, Erum Jamall, Grace Wild, David Hartin, Rebecca Francis, Genevieve Nguya, Deborah Beeby
{"title":"Bivalent prefusion F vaccination in pregnancy and respiratory syncytial virus hospitalisation in infants in the UK: results of a multicentre, test-negative, case-control study","authors":"Thomas C Williams PhD, Robin Marlow PhD, Prof Steve Cunningham PhD, Simon B Drysdale PhD, Helen E Groves MB BCh BAO PhD, Samantha Hunt BSc, Dalia Iskander PhD, Xinxue Liu PhD, Mark D Lyttle MBChB, Chengetai D Mpamhanga MSc, Shaun O'Hagan MB BCh BAO, Thomas Waterfield PhD, Damian Roland PhD, PERUKI & BronchStart Collaboration, Catriona M Middleton, Maggie Connon, Jill M Paxton, Nicola Thomson, James Thomas Baker, Susie R Hardwick, Karena Jan Fraser, Kathryn Frances Kimber, Asa JE French, Meriel FJ Tolhurst-Cleaver, Sarah Siner, Stephen Fletcher, Karen Geoghegan, Laura Ann Tremarco, Kelly Curran, Cynthia Dzokoto Diaba, Chidinma Joanne Iheanetu-Oguejiofor, Lobsong Dolma, Stephen Waithaka Ruo, Richard Benjamin Stuart Berg, Sara Mohammed Osman Farah, Elena Kehtarnavaz, Abigail Louise Whitehouse, Grace E Wild, Sobia Siraj, Ioannis Kyrgios, Amutha Anpananthar, Lee James Tubman, Sunil S Bhopal, Jessica Reynolds, Gabrielle Larkin, Elizabeth Ledger, Ruth E Bonsor, Dodd Hopgood, Robert Eggen, Katy Lillie, Mat Stuart, Alison O'Kelly, Chiara De Leonardis, Stephen P Brearey, Caroline A Burchett, Sarah E de-Beger, Claire Bell, Babu G Benjamin, Sarah E Farmer, Mudiyur Gopi, Natalie Keenan, Jen G Browning, Caroline Blackstock, Rachel O'Brien, Sylvester S Gomes, Gracita M Woods, Dilini Vasanthakumar, Kayleigh Kanhai, Heather J Jarman, Zee R Karame, Steve J Foster, Susanne Cathcart, Louise E Edwards, James R Poole-Cowley, Samantha E Hunt, Joanne L Tomlinson, Jo William Tillett, Simon R Dowson, Surendra T Singham, Perpetual S Palmer, Eilidh E Grant, Pauline Miller, Kelum K Perera, Jasmine L Stares, Manuela E Brazil, Sharryn Gardner, Kerri Bowness, Moira Morrison, Nicholas Richens, Heather Deall, Jemma Parratt, Stephanie - Grigsby, Nina Vanner, Francesca Diaz, Graham Johnson, Jonathan Riley, Alison Fletcher, Lianne Hufton, Alison Rockey, Alison Matthews, Claire Fearn, Elisha Cousins, Katie Louise Bub, Cynthia Dzokoto Diaba, Chidinma Joanne Iheanetu-Oguejiofor, Lobsong Dolma, Stephen Waithaka Ruo, Elena Kehtarnavaz, George R Hamson, Hannah Randall, Jessica J Evans, Virginia J Griffiths, Sarah L Diment, Sebastian J Gray, Nikki Leanne Furness, Stuart Gormley, Rebecca Scott, Victoria Bamber, Kathryn Jones, Megan Wilcock, Louise A Fairlie, Rophy Ganancial Nunes, Niall G Mullen, Clare O'Leary, Kerri Bowness, Richard George Burridge, Katrina S Hall, Leanne M Taylor, Lily J Kirkpatrick, Erum Jamall, Grace Wild, David Hartin, Rebecca Francis, Genevieve Nguya, Deborah Beeby","doi":"10.1016/s2352-4642(25)00155-5","DOIUrl":null,"url":null,"abstract":"Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infections (ALRI) in infants younger than 6 months globally. A maternal bivalent RSV prefusion F (RSVpreF) vaccine was introduced to the UK in late summer in 2024 (August 12 in Scotland and September 1 in England), with all pregnant women at 28 weeks or more of gestation eligible for vaccination. We aimed to understand RSVpreF vaccine effectiveness in a real-world setting.","PeriodicalId":94246,"journal":{"name":"The Lancet. Child & adolescent health","volume":"96 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Lancet. Child & adolescent health","FirstCategoryId":"0","ListUrlMain":"https://doi.org/10.1016/s2352-4642(25)00155-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infections (ALRI) in infants younger than 6 months globally. A maternal bivalent RSV prefusion F (RSVpreF) vaccine was introduced to the UK in late summer in 2024 (August 12 in Scotland and September 1 in England), with all pregnant women at 28 weeks or more of gestation eligible for vaccination. We aimed to understand RSVpreF vaccine effectiveness in a real-world setting.
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