Research on the synthesis of trifluoromethyl-substituted isoquinoline-1,3(2h,4h)-diones via decarboxylative radical addition/cyclization reaction

IF 1.7 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Fluorine Chemistry Pub Date : 2025-07-01 DOI:10.1016/j.jfluchem.2025.110456

Yu Zhang , Bao Feng Du , Jinpeng Miao , Xian Jin Yang

引用次数: 0

Abstract

A transition-metal-free radical addition/cyclization reaction has been developed for the synthesis of Isoquinoline-1,3(2H,4H)‑dione derivatives by the decarboxylation of 3,3,3-trifluoro-2,2-dimethylpropanoic acid and N-methylacrylamide. This mild and convenient method provides a new synthetic route for introducing C(CF₃)Me₂ group into the Isoquinoline-1,3(2H,4H)‑dione scaffold, which exhibits a wide functional group tolerance and features substrate scope.

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脱羧自由基加成/环化反应合成三氟甲基取代异喹啉-1,3(2h,4h)-二酮的研究

以3,3,3-三氟-2,2-二甲基丙酸和n-甲基丙烯酰胺脱羧为原料，建立了过渡金属自由基加成/环化反应，合成了异喹啉-1,3（2H,4H）二酮衍生物。该方法温和简便，为在异喹啉-1,3(2H,4H) -二酮支架中引入C(CF3)Me2基团提供了一条新的合成途径，具有广泛的官能团耐受性和底物范围。

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来源期刊

Journal of Fluorine Chemistry 化学-无机化学与核化学

CiteScore

3.80

自引率

10.50%

发文量

审稿时长

33 days

期刊介绍： The Journal of Fluorine Chemistry contains reviews, original papers and short communications. The journal covers all aspects of pure and applied research on the chemistry as well as on the applications of fluorine, and of compounds or materials where fluorine exercises significant effects. This can include all chemistry research areas (inorganic, organic, organometallic, macromolecular and physical chemistry) but also includes papers on biological/biochemical related aspects of Fluorine chemistry as well as medicinal, agrochemical and pharmacological research. The Journal of Fluorine Chemistry also publishes environmental and industrial papers dealing with aspects of Fluorine chemistry on energy and material sciences. Preparative and physico-chemical investigations as well as theoretical, structural and mechanistic aspects are covered. The Journal, however, does not accept work of purely routine nature. For reviews and special issues on particular topics of fluorine chemistry or from selected symposia, please contact the Regional Editors for further details.