[Age-period-cohort analysis on disease burden of Chlamydia trachomatis infection in women aged 15-49 years in China, 1990-2021].

Q1 Medicine

中华流行病学杂志 Pub Date : 2025-07-10 DOI:10.3760/cma.j.cn112338-20250101-00002

Y Q Yang, X D Ye, Q Luo, W P He, C Mao

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引用次数: 0

Abstract

Objective: To analyze the incidence rate and disability-adjusted life year (DALY) rate of Chlamydia trachomatis (C. trachomatis) infection in women aged 15-49 years in China from 1990 to 2021, identify the vulnerable populations, and provide evidence for the prevention and control of C. trachomatis infection. Methods: The data from Global Burden of Disease Study 2021 were used to analyze the incidence rate and DALY rate of C. trachomatis infection in women aged 15-49 years in China from 1990 to 2021 by using Joinpoint regression model. The age-period-cohort analysis method was used to decompose the age effect, period effect and cohort effect of incidence rate and DALY rate of C. trachomatis infection. Results: From 1990 to 2021, the incidence rate of C. trachomatis infection increased from 5 892.02/100 000 in 1990 to 7 402.23/100 000 in 2021 in women aged 15-49 years in China. The DALY rate increased from 1.92/100 000 person-years in 1990 to 2.00/100 000 person-years in 2021. Joinpoint regression showed that, from 1990 to 2021, the annual incidence of C. trachomatis infection in Chinese women age aged 15-49 years increased by 0.74% [average annual percent change (AAPC) =0.74%, 95%CI: 0.67%-0.81%, t=21.94, P<0.001] and the annual average DALY rate increased by 0.11% (AAPC=0.11%, 95%CI: -0.09%-0.30%, t=1.06, P=0.287). Age-period-cohort model analyses showed that women aged 30-34 years were at high risk to be infected with C. trachomatis and women aged 40-44 years were at high risk to have high DALY. The period effect showed that the risk for C. trachomatis infection began to increase in 1990, peaked during 2000-2004, then gradually decreased. During 2015-2019, the infection risk increased again, while the risk for high DALY showed a decreasing trend. The cohort effect showed that the risks for C. trachomatis infection and DALY were lower in later birth cohorts. Conclusions: From 1990 to 2021, the incidence rate and DALY rate of C. trachomatis infection showed fluctuations in women aged 15-49 years in China. It is necessary to pay close attention to the prevention and control of C. trachomatis infection in women aged 30-34 years.

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[1990-2021年中国15-49岁女性沙眼衣原体感染疾病负担的年龄-时期-队列分析]。

目的：分析1990 - 2021年中国15-49岁女性沙眼衣原体（C.沙眼）感染发病率及伤残调整生命年（DALY）率，确定易感人群，为沙眼衣原体感染防控提供依据。方法：利用《2021年全球疾病负担研究》的数据，采用Joinpoint回归模型分析1990 - 2021年中国15-49岁女性沙眼衣原体感染的发病率和DALY率。采用年龄-时期-队列分析方法对沙眼衣原体感染率和DALY感染率的年龄效应、时期效应和队列效应进行分解。结果：1990 ~ 2021年，中国15 ~ 49岁女性沙眼原体感染率由1990年的5 892.02/10万上升至2021年的7 402.23/10万。DALY率从1990年的1.92/10万人-年上升到2021年的2.00/10万人-年。联合点回归显示，1990 - 2021年，我国15-49岁女性沙眼衣原体年感染率上升0.74%[年均变化率(AAPC) =0.74%, 95%CI: 0.67% ~ 0.81%, t=21.94, PCI: -0.09% ~ 0.30%, t=1.06， P=0.287]。年龄-时期-队列模型分析显示，30-34岁女性感染沙眼衣原体的风险较高，40-44岁女性感染沙眼衣原体的风险较高。时期效应表明，沙眼衣原体感染风险从1990年开始上升，2000-2004年达到高峰，随后逐渐下降。2015-2019年感染风险再次上升，高DALY风险呈下降趋势。队列效应显示，出生较晚的队列中沙眼衣原体感染和DALY的风险较低。结论：1990 - 2021年，中国15-49岁女性沙眼衣原体感染发病率和DALY呈波动趋势。应高度重视30 ~ 34岁女性沙眼原体感染的预防和控制。

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来源期刊

中华流行病学杂志 Medicine-Medicine (all)

CiteScore

5.60

自引率

0.00%

发文量

8981

期刊介绍： Chinese Journal of Epidemiology, established in 1981, is an advanced academic periodical in epidemiology and related disciplines in China, which, according to the principle of integrating theory with practice, mainly reports the major progress in epidemiological research. The columns of the journal include commentary, expert forum, original article, field investigation, disease surveillance, laboratory research, clinical epidemiology, basic theory or method and review, etc. The journal is included by more than ten major biomedical databases and index systems worldwide, such as been indexed in Scopus, PubMed/MEDLINE, PubMed Central (PMC), Europe PubMed Central, Embase, Chemical Abstract, Chinese Science and Technology Paper and Citation Database (CSTPCD), Chinese core journal essentials overview, Chinese Science Citation Database (CSCD) core database, Chinese Biological Medical Disc (CBMdisc), and Chinese Medical Citation Index (CMCI), etc. It is one of the core academic journals and carefully selected core journals in preventive and basic medicine in China.