The association between life's essential 8 health behavior component score and all-cause and cardiovascular mortality among U.S. adults with cardiovascular-kidney-metabolic syndrome stages 0-3.

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine Pub Date : 2025-07-16 DOI:10.1016/j.ypmed.2025.108360

Yifei Wang, Tianshan Dong, Bin Wang, Ping Zhang

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引用次数: 0

Abstract

Objective: To investigate the association between Life's Essential 8 (LE8) health behavior component score and mortality outcomes among individuals with Cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3.

Methods: 8067 U.S. adults from the National Health and Nutrition Examination Survey 2005-2018, aged 30-79 years with CKM syndrome stages 0-3, were analyzed. Mortality status was obtained via linkage to the National Death Index through December 31, 2019. Kaplan-Meier analysis, multivariable Cox regression, and restricted cubic splines (RCS) were used to examine associations between LE8 health behavior component score and mortality outcomes.

Results: CKM stages were distributed as follows: 7.8 % (stage 0), 21.0 % (stage 1), 64.0 % (stage 2), and 7.3 % (stage 3). Higher LE8 total score and health behavior component score were linked to reduction in all-cause mortality and cardiovascular mortality risk. RCS analysis showed a linear relationship between LE8 total score, health behavior component score and mortality outcomes. Interaction between health behavior component score and CKM syndrome stages was identified for all-cause mortality.

Conclusions: Higher LE8 health behavior component score is associated with reduced all-cause and cardiovascular mortality among population with CKM syndrome stages 0-3. These findings support the potential value of behavior-targeted interventions tailored to CKM syndrome stages.

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美国成人心血管-肾脏-代谢综合征0-3期患者的生活基本健康行为成分评分与全因死亡率和心血管死亡率之间的关系。

目的：探讨心血管肾代谢综合征（CKM） 0-3期患者生命基本8 （LE8）健康行为成分评分与死亡结局的关系。方法:8067年 美国分析2005-2018年全国健康与营养调查中年龄在30-79 岁、CKM综合征0-3期的成年人。通过与截至2019年12月31日的国家死亡指数的联系获得死亡率状况。采用Kaplan-Meier分析、多变量Cox回归和限制性三次样条（RCS）检验LE8健康行为成分评分与死亡结局之间的关系。结果：CKM分期分布为：7.8 %（0期）、21.0 %（1期）、64.0 %（2期）、7.3 %（3期）。较高的LE8总分和健康行为成分评分与全因死亡率和心血管死亡风险的降低有关。RCS分析显示LE8总分、健康行为成分评分与死亡结局呈线性关系。健康行为成分评分与CKM综合征分期之间的相互作用被确定为全因死亡率。结论：在CKM综合征0-3期人群中，较高的LE8健康行为成分评分与全因死亡率和心血管死亡率降低相关。这些发现支持针对CKM综合征阶段进行针对性行为干预的潜在价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Preventive medicine 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.70

自引率

3.90%

发文量

审稿时长

42 days

期刊介绍： Founded in 1972 by Ernst Wynder, Preventive Medicine is an international scholarly journal that provides prompt publication of original articles on the science and practice of disease prevention, health promotion, and public health policymaking. Preventive Medicine aims to reward innovation. It will favor insightful observational studies, thoughtful explorations of health data, unsuspected new angles for existing hypotheses, robust randomized controlled trials, and impartial systematic reviews. Preventive Medicine''s ultimate goal is to publish research that will have an impact on the work of practitioners of disease prevention and health promotion, as well as of related disciplines.