Performance (Sensitivity and Specificity) of a New Point-of-Care Immunochromatography to Screen for Imported Chronic Schistosomiasis Among Long-Term Sub-Saharan Migrants.

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2025-07-17 eCollection Date: 2025-07-01 DOI:10.1093/ofid/ofaf328

Alaa H A Hegazy, Olga Pérez-Quílez, Israel López-Muñoz, Anna Chamorro, Elena Abad, Alba San José, Júlia Valera, Lluís Valerio, Laura Soldevila, Ester Gorriz, Dolores Herena, Elia Fernández-Pedregal, Josep M Llibre, Gema Fernández-Rivas, Pere Joan Cardona, Xavier Vallès, Sílvia Roure

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引用次数: 0

Abstract

Background: Imported schistosomiasis is underdiagnosed among long-term migrants in non-endemic countries. Reference standard tests are lacking for the diagnosis of chronic schistosomiasis.

Methods: This study evaluated the sensitivity and specificity of a new immunochromatography (ICT) test using serum (s) or point-of-care finger-prick (FP) whole blood against standard serological tests in long-term migrants from sub-Saharan Africa.

Results: A total of 202 individuals were screened, with a mean age of 42.7 years. Of these, 75.7% were male, and 42.6% were from Senegal. Test positivity rates were 15.8% for ELISA, 24.3% for ICT-p, 46.5% for ICT-b (s), and 28.7% for ICT-b (FP). All tests showed good agreement with a clinical score but with heterogeneous agreement between them. Our results indicates a higher sensitivity for ICT-b (s). Positive responses after treatment suggest good specificity for all tests.

Conclusions: ICT-b (s) shows a higher sensitivity than the other standard tests. An ICT-b (FP) strategy could be used as a first-step point-of-care screening tool for probable chronic schistosomiasis.

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一种新的即时免疫层析筛查撒哈拉以南长期移民中输入性慢性血吸虫病的性能（敏感性和特异性）

背景：在非流行国家的长期移民中，输入性血吸虫病的诊断不足。缺乏诊断慢性血吸虫病的参考标准试验。方法：本研究评估了一种新的免疫层析（ICT）试验的敏感性和特异性，该试验使用血清或即时点指刺血（FP）全血，与撒哈拉以南非洲长期移民的标准血清学试验相比。结果：共筛查202例，平均年龄42.7岁。其中75.7%为男性，42.6%来自塞内加尔。ELISA阳性率为15.8%，ICT-p阳性率为24.3%,ICT-b (s)阳性率为46.5%,ICT-b （FP）阳性率为28.7%。所有试验均显示与临床评分有良好的一致性，但它们之间存在异质性一致性。我们的结果表明ICT-b (s)具有更高的灵敏度。治疗后的阳性反应表明所有检查的特异性都很好。结论：ICT-b (s)具有较高的敏感性。ICT-b （FP）战略可作为潜在慢性血吸虫病的第一步即时筛查工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.