{"title":"Gut microbes and their metabolites in relation to the classic tumor suppressor gene P53: a novel narrative.","authors":"Jia-Xuan Li, Chen-Guang Liu, Jun Chen","doi":"10.1038/s41522-025-00775-x","DOIUrl":null,"url":null,"abstract":"<p><p>Gut microbes are considered to be key factors regulating host health and are closely related to tumorigenesis. Although the exact mechanism has not been clearly explained, many studies have shown that specific bacteria can affect cancer-related bioactive molecules, such as p53, Wnt, MAPK, and EGFR. Among them, p53 is the most commonly mutated gene in all tumor types. In this review, we systematically examine the gut microbes and metabolites that affect the tumor process by regulating p53, as well as the role of p53 in shaping the gut microbiota, and discuss their potential in the diagnosis and prognosis of tumors and the application value of clinical anti-tumor therapy. This study provides an important theoretical basis for the in-depth understanding and development of relevant treatment strategies.</p>","PeriodicalId":19370,"journal":{"name":"npj Biofilms and Microbiomes","volume":"11 1","pages":"135"},"PeriodicalIF":9.2000,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271359/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"npj Biofilms and Microbiomes","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41522-025-00775-x","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Gut microbes are considered to be key factors regulating host health and are closely related to tumorigenesis. Although the exact mechanism has not been clearly explained, many studies have shown that specific bacteria can affect cancer-related bioactive molecules, such as p53, Wnt, MAPK, and EGFR. Among them, p53 is the most commonly mutated gene in all tumor types. In this review, we systematically examine the gut microbes and metabolites that affect the tumor process by regulating p53, as well as the role of p53 in shaping the gut microbiota, and discuss their potential in the diagnosis and prognosis of tumors and the application value of clinical anti-tumor therapy. This study provides an important theoretical basis for the in-depth understanding and development of relevant treatment strategies.
期刊介绍：
npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.
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