A new dipeptide from entomogenous fungus Metapochonia suchlasporia Y9.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-07-18 DOI:10.1080/14786419.2025.2532841

Hong-Yan Yang, Jia-Qian Yang, Zhi-Pu Huang, Ke-Tao Zhang, Xin-Yi Chen, Jin-Li Zhao, Yan Wang, Qing Zhao, Xiao-Mei Zhang

引用次数: 0

Abstract

A new dipeptide compound, namely N-[(Phenylmethoxy) carbonyl]-L-m-tyrosyl-L-proline methyl ester (1), along with six identified nature products were separated from the entomogenous fungus Metapochonia suchlasporia Y9. 1D and 2D NMR spectroscopic data, MS spectroscopic data as well as HRESIMS data were used to elucidate the chemical structures of these compounds. For the new dipeptide 1, electronic circular dichroism (ECD) data and specific rotation were used to confirm its absolute configuration. In the tests of antibacterial and antifungal activities, all of the above seven compounds showed antibacterial activities with different degree while none of them showed antifungal activity at the dose of 50 ug.

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虫生真菌Metapochonia suchlasporia Y9的一个新的二肽。

从虫生真菌Metapochonia suchlasporia Y9中分离出一个新的二肽化合物N-[（苯基甲氧基）羰基]- l- m-酪氨酸- l-脯氨酸甲酯(1)和6个鉴定的天然产物。利用一维和二维核磁共振光谱数据、质谱数据以及hremms数据对这些化合物的化学结构进行了分析。对于新二肽1，利用电子圆二色性（ECD）数据和比旋光度来确定其绝对构型。在抗菌和抗真菌活性测试中，上述7种化合物均表现出不同程度的抗菌活性，而在50 ug剂量下均未表现出抗真菌活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.