Cong Zhang, Yong-Wen Ouyang, Hui-Xin He, Pei-Zhu Su, Zhao-Tao Li
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引用次数: 0
Abstract
Chemokine (C-C) ligand 17 (CCL17) is a key molecule that mediates immune cell migration and inflammation. As a ligand for the type 4 C-C chemokine receptor (CCR4), CCL17 mainly affects T cells, but also influences other cell types, suggesting a broader role in immune regulation. This review comprehensively demonstrates the molecular structure and function of CCL17, its interaction with CCR4, and its involvement in the pathogenesis of inflammatory bowel disease (IBD). Additionally, we also discuss how CCL17 regulates the behavior of various immune cells, including T cells, dendritic cells, monocytes/macrophages, eosinophils, neutrophils, and fibroblasts, highlighting its involvement in the pathogenesis of IBD and its potential contribution to IBD-related colon cancer. In conclusion, this review emphasizes the important role of CCL17 in the pathogenesis of IBD and its potential as a therapeutic target.
期刊介绍：
Journal of Gastroenterology and Hepatology is produced 12 times per year and publishes peer-reviewed original papers, reviews and editorials concerned with clinical practice and research in the fields of hepatology, gastroenterology and endoscopy. Papers cover the medical, radiological, pathological, biochemical, physiological and historical aspects of the subject areas. All submitted papers are reviewed by at least two referees expert in the field of the submitted paper.
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