Advances in Molecularly Imprinted Polymers for Bone Biomarker Detection and Therapeutic Applications.

IF 2.5 4区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Ren Yang, Xiaohan Ma, Mingcheng Xuan, Yingqi Ma, Jiexian Ding, David Y S Chau, Jonathan C Knowles, Feng Peng, Alessandro Poma
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引用次数: 0

Abstract

This review explores the application of molecularly imprinted polymers (MIPs) in detecting bone turnover biomarkers and advancing osteogenic treatment strategies. MIPs, designed to mimic biological recognition sites, offer innovative solutions for precise molecular recognition in bone health management. Chemical methodologies for MIPs synthesis and their integration into diagnostic systems for detecting bone resorption markers are highlighted. Furthermore, MIP-driven therapeutic advancements, including controlled drug release, cell imprinting for osteogenic differentiation, and functional scaffolds for tissue regeneration, are emphasized. This review underscores MIPs' potential to revolutionize bone disease management and calls for further exploration into chemical designs to optimize their clinical and practical applications.

分子印迹聚合物在骨生物标志物检测及治疗中的应用进展。
本文综述了分子印迹聚合物(MIPs)在检测骨转换生物标志物和推进成骨治疗策略方面的应用。MIPs旨在模拟生物识别位点,为骨骼健康管理中的精确分子识别提供创新的解决方案。化学方法的MIPs合成和他们集成到诊断系统检测骨吸收标记突出。此外,还强调了mip驱动的治疗进展,包括药物释放控制、成骨分化的细胞印迹和组织再生的功能支架。这篇综述强调了MIPs在骨疾病管理方面的革命性潜力,并呼吁进一步探索化学设计以优化其临床和实际应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ChemistryOpen
ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
4.80
自引率
4.30%
发文量
143
审稿时长
1 months
期刊介绍: ChemistryOpen is a multidisciplinary, gold-road open-access, international forum for the publication of outstanding Reviews, Full Papers, and Communications from all areas of chemistry and related fields. It is co-owned by 16 continental European Chemical Societies, who have banded together in the alliance called ChemPubSoc Europe for the purpose of publishing high-quality journals in the field of chemistry and its border disciplines. As some of the governments of the countries represented in ChemPubSoc Europe have strongly recommended that the research conducted with their funding is freely accessible for all readers (Open Access), ChemPubSoc Europe was concerned that no journal for which the ethical standards were monitored by a chemical society was available for such papers. ChemistryOpen fills this gap.
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