Global warming risks dehydrating and inflaming human airways.

IF 8.9 1区 地球科学 Q1 ENVIRONMENTAL SCIENCES
Communications Earth & Environment Pub Date : 2025-01-01 Epub Date: 2025-03-17 DOI:10.1038/s43247-025-02161-z
David A Edwards, Aurélie Edwards, Dan Li, Linying Wang, Kian Fan Chung, Deen Bhatta, Andreas Bilstein, Justin Hanes, Indika Endirisinghe, Britt Burton Freeman, Mark Gutay, Alessandra Livraghi-Butrico, Brian Button
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引用次数: 0

Abstract

Global warming increases water evaporation rates from planetary ecosystems. Here, we show that evaporation rates encountered during human breathing in dehydrating atmospheres promotes airway inflammation and potentially exacerbates lung diseases. Continuum mathematical analysis predicts that water evaporation thins airway mucus layers and compresses epithelial cells during tidal breathing. Experiments using human tracheal-bronchial cells confirm that exposure to air with progressive degrees of dryness (relative humidities of 95%, 60% and 30% at 37°C) causes the mucus layer to progressively thin (by 5%, 35%, and 58%). Associated compression of epithelial cells elevates secretion of inflammatory cytokines ( TNF-α , IL-33, and IL-6). Exposing mice with a muco-inflammatory phenotype to intermittent dry air for 7 days results in histopathological changes and alteration of inflammatory infiltrates. Together with climate model simulations, these findings suggest that most of the United States will be at elevated risk of airway inflammation by the latter half of this century.

全球变暖可能导致人体呼吸道脱水和发炎。
全球变暖增加了地球生态系统的水分蒸发速率。在这里,我们表明,在脱水的大气中,人体呼吸过程中遇到的蒸发速率会促进气道炎症,并可能加剧肺部疾病。连续统数学分析预测,在潮汐呼吸期间,水蒸发使气道黏液层变薄并压缩上皮细胞。使用人体气管-支气管细胞的实验证实,暴露于逐渐干燥的空气中(37°C时相对湿度为95%、60%和30%)会导致黏液层逐渐变薄(变薄5%、35%和58%)。相关的上皮细胞压迫会增加炎性细胞因子(TNF-α、IL-33和IL-6)的分泌。将具有粘膜炎症表型的小鼠暴露于间歇性干燥空气中7天会导致组织病理学变化和炎症浸润的改变。结合气候模型模拟,这些发现表明,到本世纪下半叶,美国大部分地区将面临气道炎症的高风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Communications Earth & Environment
Communications Earth & Environment Earth and Planetary Sciences-General Earth and Planetary Sciences
CiteScore
8.60
自引率
2.50%
发文量
269
审稿时长
26 weeks
期刊介绍: Communications Earth & Environment is an open access journal from Nature Portfolio publishing high-quality research, reviews and commentary in all areas of the Earth, environmental and planetary sciences. Research papers published by the journal represent significant advances that bring new insight to a specialized area in Earth science, planetary science or environmental science. Communications Earth & Environment has a 2-year impact factor of 7.9 (2022 Journal Citation Reports®). Articles published in the journal in 2022 were downloaded 1,412,858 times. Median time from submission to the first editorial decision is 8 days.
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