Choosing among the long-acting injectable antipsychotics: an evidence-based pragmatic guide.

IF 4.1 3区 医学 Q2 CLINICAL NEUROLOGY
Leslie Citrome
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引用次数: 0

Abstract

In this review, the aim is to differentiate between the 3 second-generation antipsychotics available as long-acting injectables (risperidone/paliperidone, aripiprazole, and olanzapine) and their varied formulations. Differences and similarities among the available products are discussed, including the amenities of care: route of administration (intramuscular or subcutaneous), injection frequency, needle gauge and length, injection volume, injection site, reconstitution procedures, initiation with oral medication or multiple injections, refrigeration requirements, post-injection observation requirements, drug-drug interactions preventing use or requiring dosing adjustments, adjustments requirements for late or missed doses, availability of patient assistance programs, and access barriers for off-label use. Effectiveness in acute and maintenance treatment are reviewed using the metrics of number needed to treat and number needed to harm.

选择长效注射抗精神病药物:循证实用指南。
在这篇综述中,目的是区分3种第二代长效注射抗精神病药物(利培酮/帕利哌酮、阿立哌唑和奥氮平)及其不同的配方。讨论了现有产品的差异和相似之处,包括护理的便利设施:给药途径(肌肉注射或皮下注射)、注射频率、针规和长度、注射量、注射部位、重构程序、开始口服或多次注射、冷藏要求、注射后观察要求、药物-药物相互作用、防止使用或需要调整剂量、迟给或漏给剂量的调整要求、患者援助计划的可用性,以及超说明书使用的准入障碍。使用治疗所需的数量和伤害所需的数量来评估急性治疗和维持治疗的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CNS Spectrums
CNS Spectrums 医学-精神病学
CiteScore
6.20
自引率
6.10%
发文量
239
审稿时长
>12 weeks
期刊介绍: CNS Spectrums covers all aspects of the clinical neurosciences, neurotherapeutics, and neuropsychopharmacology, particularly those pertinent to the clinician and clinical investigator. The journal features focused, in-depth reviews, perspectives, and original research articles. New therapeutics of all types in psychiatry, mental health, and neurology are emphasized, especially first in man studies, proof of concept studies, and translational basic neuroscience studies. Subject coverage spans the full spectrum of neuropsychiatry, focusing on those crossing traditional boundaries between neurology and psychiatry.
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